8U32

Crystal structure of PD-1 in complex with a Fab

Summary for 8U32

• Entry DOI: 10.2210/pdb8u32/pdb
• Descriptor: Programmed cell death protein 1, Fab light chain, Fab heavy chain, ... (5 entities in total)
• Functional Keywords: pd-1, fab, structural protein, structural protein-immune system complex, structural protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 127014.39

Authors

Sun, D.,Masureel, M. (deposition date: 2023-09-07, release date: 2024-06-19)

• Primary citation: Liang, W.C.,Xi, H.,Sun, D.,D'Ascenzo, L.,Zarzar, J.,Stephens, N.,Cook, R.,Li, Y.,Ye, Z.,Matsumoto, M.,Payandeh, J.,Masureel, M.,Wu, Y.; Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.; Mabs, 16:2309685-2309685, 2024; PubMed: 38356181; DOI: 10.1080/19420862.2024.2309685

Experimental method

X-RAY DIFFRACTION (2.51 Å)