8U32

Crystal structure of PD-1 in complex with a Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Programmed cell death protein 1	polymer	140	15765.3	2	UniProt (Q15116) Pfam (PF07686) In PDB	Homo sapiens (human)
2	B, E	Fab light chain	polymer	218	23509.8	2		Homo sapiens (human)
3	C, F	Fab heavy chain	polymer	229	24010.9	2		Homo sapiens (human)
4	D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5		water	water		18.0	145	Chemie (HOH)

Sequence modifications

A, D: 25 - 146 (UniProt: Q15116)

PDB	External Database	Details
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
Gly 16	-	expression tag
Glu 17	-	expression tag
Asn 18	-	expression tag
Leu 19	-	expression tag
Tyr 20	-	expression tag
Phe 21	-	expression tag
Gln 22	-	expression tag
Gly 23	-	expression tag
Ser 24	-	expression tag
Ser 93	Cys 93	engineered mutation
Gly 147	-	expression tag
Asn 148	-	expression tag
Ser 149	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	126572.0
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	127014.4

*Water molecules are not included.