8P1O
Solubilizer tag effect on PD-L1/inhibitor binding properties for m-terphenyl derivatives
Summary for 8P1O
Entry DOI | 10.2210/pdb8p1o/pdb |
Descriptor | Programmed cell death 1 ligand 1, (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | pd-l1, immune checkpoint, small-molecule inhibitor, cancer, m-terphenyl, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 34254.56 |
Authors | Plewka, J.,Magiera-Mularz, K.,Surmiak, E.,Kalinowska-Tluscik, J.,Holak, T.A. (deposition date: 2023-05-12, release date: 2024-01-31) |
Primary citation | Surmiak, E.,Zaber, J.,Plewka, J.,Wojtanowicz, G.,Kocik-Krol, J.,Kruc, O.,Muszak, D.,Rodriguez, I.,Musielak, B.,Viviano, M.,Castellano, S.,Skalniak, L.,Magiera-Mularz, K.,Holak, T.A.,Kalinowska-Tluscik, J. Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. Acs Med.Chem.Lett., 15:36-44, 2024 Cited by PubMed: 38229762DOI: 10.1021/acsmedchemlett.3c00306 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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