8P1O
Solubilizer tag effect on PD-L1/inhibitor binding properties for m-terphenyl derivatives
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Programmed cell death 1 ligand 1 | polymer | 144 | 16734.3 | 2 | UniProt (Q9NZQ7) Pfam (PF07686) In PDB | Homo sapiens (human) | PD-L1,PDCD1 ligand 1,Programmed death ligand 1,hPD-L1,B7 homolog 1,B7-H1 |
2 | A | (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide | non-polymer | 523.0 | 1 | Chemie (WEW) | |||
3 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
5 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 133 (UniProt: Q9NZQ7)
PDB | External Database | Details |
---|---|---|
Ala 134 | - | expression tag |
Ala 135 | - | expression tag |
Ala 136 | - | expression tag |
Leu 137 | - | expression tag |
Glu 138 | - | expression tag |
His 139 | - | expression tag |
His 140 | - | expression tag |
His 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
His 144 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 33468.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 786.1 | |
All* | Total formula weight | 34254.6 |