8THH

Cryo-EM structure of Nav1.7 with LTG

Summary for 8THH

• Entry DOI: 10.2210/pdb8thh/pdb
• EMDB information: 41262
• Descriptor: Sodium channel protein type 9 subunit alpha, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Sodium channel subunit beta-1, ... (11 entities in total)
• Functional Keywords: cryo-em, sodium channel, vgsc, nav1.7, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 286764.04

Authors

Fan, X.,Huang, J.,Yan, N. (deposition date: 2023-07-16, release date: 2023-11-22)

• Primary citation: Huang, J.,Fan, X.,Jin, X.,Teng, L.,Yan, N.; Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine.; Proc.Natl.Acad.Sci.USA, 120:e2309773120-e2309773120, 2023; PubMed: 37782796; DOI: 10.1073/pnas.2309773120

Experimental method

ELECTRON MICROSCOPY (2.7 Å)