8THH
Cryo-EM structure of Nav1.7 with LTG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium channel protein type 9 subunit alpha | polymer | 1988 | 226620.0 | 1 | UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF24609) | Homo sapiens (human) | Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7 |
| 2 | B (B) | Sodium channel subunit beta-1 | polymer | 218 | 24732.1 | 1 | UniProt (Q07699) Pfam (PF07686) | Homo sapiens (human) | |
| 3 | C (C) | Sodium channel subunit beta-2 | polymer | 215 | 24355.9 | 1 | UniProt (O60939) Pfam (PF07686) | Homo sapiens (human) | |
| 4 | D, E, F (D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | AA, G, H, Y, Z (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | I, J (A) | (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine | non-polymer | 256.1 | 2 | Chemie (IYJ) PubChem (3878) | |||
| 7 | K, L, M, X (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 8 | N, P, T, U, V... (A) | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 510.7 | 6 | Chemie (LPE) PubChem (3855) PubChem (9546711) PubChem (446876) | |||
| 9 | O, Q, S (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 3 | Chemie (PCW) | |||
| 10 | R (A) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 1 | Chemie (P5S) PubChem (9547075) PubChem (10417847) PubChem (9547096) PubChem (15409341) PubChem (165429904) PubChem (125040277) PubChem (133612130) | |||
| 11 | BA, CA (A, B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 275708.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 9782.8 | |
| All* | Total formula weight | 286764.0 |
