PDB: 1901 件ウェブページステータス検索Chemie searchBIRD

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3HUC	Human p38 MAP Kinase in Complex with RL40 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 14, N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide, ... 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2009-06-13 公開日 2010-03-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
7N5C	6218 TCR in complex with H2Db PA with an engineered TCR-pMHC disulfide bond 分子名称: Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 with T-cell receptor, sp3.4 alpha chain, ... 著者 Szeto, C, Gras, S. 登録日 2021-06-05 公開日 2022-07-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
6SIS	Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB 分子名称: Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... 著者 Hughes, S.J, Testa, A, Ciulli, A. 登録日 2019-08-10 公開日 2019-12-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure-Based Design of a Macrocyclic PROTAC. Angew.Chem.Int.Ed.Engl., 59, 2020
7S4E	Crystal Structure of ligand ACBi1 in complex with bromodomain of human Smarca2 and pVHL:ElonginC:ElonginB complex 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Elongin-B, ... 著者 MacPherson, D.J, Sherman, W. 登録日 2021-09-08 公開日 2022-10-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry. Nat Commun, 13, 2022
1LWM	Solution Structure of the Sequence-Non-Specific HMGB protein NHP6A 分子名称: NONHISTONE CHROMOSOMAL PROTEIN 6A 著者 Masse, J.E, Wong, B, Yen, Y.-M, Allain, F.H.-T, Johnson, R.C, Feigon, J. 登録日 2002-05-31 公開日 2002-10-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding J.Mol.Biol., 323, 2002
5MHC	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, ... 著者 Andrei, S, Ottmann, C, Leysen, S. 登録日 2016-11-24 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
7PT6	Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 7, DDK kinase regulatory subunit DBF4, ... 著者 Saleh, A, Noguchi, Y, Aramayo, R, Ivanova, M.E, Speck, C. 登録日 2021-09-26 公開日 2022-06-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nat Commun, 13, 2022
8BI7	Binary structure of 14-3-3s and PKR phosphopeptide 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, PKR phosphopeptide 著者 Somsen, B.A, Ottmann, C. 登録日 2022-11-01 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
7N4K	6218 TCR in complex with H2-Db PA 224 分子名称: Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 and T-cell receptor, sp3.4 alpha chain, ... 著者 Szeto, C, Gras, S. 登録日 2021-06-04 公開日 2022-07-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
7N5P	6218 TCR in complex with H2-Db PA224-233 with a cysteine mutant 分子名称: Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 and T-cell receptor, sp3.4 alpha chain, ... 著者 Szeto, C, Gras, S. 登録日 2021-06-06 公開日 2022-07-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
7N5Q	Peptide-MHC complex of mouse H2-Db presenting PA224 with E4C mutation 分子名称: ACETATE ION, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... 著者 Szeto, C, Gras, S. 登録日 2021-06-06 公開日 2022-07-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
5TXP	STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP 分子名称: 1,2-ETHANEDIOL, 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), ... 著者 Das, K, Martinez, S.M, Arnold, E. 登録日 2016-11-17 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob. Agents Chemother., 61, 2017
1TKX	CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745 分子名称: 4-[(CYCLOPROPYLETHYNYL)OXY]-6-FLUORO-3-ISOPROPYLQUINOLIN-2(1H)-ONE, Pol polyprotein, Reverse transcriptase, ... 著者 Ren, J, Hopkins, A.L, Stuart, D.I, Stammers, D.K. 登録日 2004-06-09 公開日 2004-12-07 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. J.Med.Chem., 47, 2004
5TXO	STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), ... 著者 Das, K, Martinez, S.M, Arnold, E. 登録日 2016-11-17 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.546 Å) 主引用文献 Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob. Agents Chemother., 61, 2017
3ZNG	Ankyrin repeat and SOCS-box protein 9 (ASB9) in complex with ElonginB and ElonginC 分子名称: 1,2-ETHANEDIOL, ANKYRIN REPEAT AND SOCS BOX PROTEIN 9, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... 著者 Thomas, J, Van Molle, I, Ciulli, A. 登録日 2013-02-14 公開日 2013-12-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Multimeric Complexes Among Ankyrin-Repeat and Socs-Box Protein 9 (Asb9), Elonginbc, and Cullin 5: Insights Into the Structure and Assembly of Ecs-Type Cullin-Ring E3 Ubiquitin Ligases. Biochemistry, 52, 2013
3HV6	Human p38 MAP Kinase in Complex with RL39 分子名称: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2009-06-15 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53, 2010
3HV5	Human p38 MAP Kinase in Complex with RL24 分子名称: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 14, ... 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2009-06-15 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53, 2010
6RFP	ERK2 MAP kinase with mutations at Helix-G 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Eitan-Wexler, M. 登録日 2019-04-16 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop. J.Biol.Chem., 295, 2020
1W0H	Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP 分子名称: 3'-5' EXONUCLEASE ERI1, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION 著者 Cheng, Y, Patel, D. 登録日 2004-06-04 公開日 2004-09-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Crystallographic Structure of the Nuclease Domain of 3'Hexo, a Deddh Family Member, Bound to Ramp J.Mol.Biol., 343, 2004
3ZKJ	Crystal Structure of Ankyrin Repeat and Socs Box-Containing Protein 9 (Asb9) in Complex with Elonginb and Elonginc 分子名称: 1,2-ETHANEDIOL, ANKYRIN REPEAT AND SOCS BOX PROTEIN 9, CHLORIDE ION, ... 著者 Muniz, J.R.C, Guo, K, Zhang, Y, Ayinampudi, V, Savitsky, P, Keates, T, Filippakopoulos, P, Vollmar, M, Yue, W.W, Krojer, T, Ugochukwu, E, von Delft, F, Knapp, S, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. 登録日 2013-01-23 公開日 2013-01-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Molecular Architecture of the Ankyrin Socs Box Family of Cul5-Dependent E3 Ubiquitin Ligases J.Mol.Biol., 425, 2013
5TXL	STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG) P*CP*GP*CP*CP*GP)-3'), ... 著者 Das, K, Martinez, S.M, Arnold, E. 登録日 2016-11-17 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob. Agents Chemother., 61, 2017
7R1Y	cryoEM structure of human Nup155 (residues 19-981) 分子名称: Nuclear pore complex protein Nup155 著者 Taniguchi, R, Beck, M. 登録日 2022-02-03 公開日 2022-06-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 AI-based structure prediction empowers integrative structural analysis of human nuclear pores. Science, 376, 2022
3O96	Crystal Structure of Human AKT1 with an Allosteric Inhibitor 分子名称: 1-(1-(4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, RAC-alpha serine/threonine-protein kinase 著者 Voegtli, W.C, Wu, W.-I, Lord-Ondash, H.A, Dizon, F.P, Vigers, G.P.A, Brandhuber, B.J. 登録日 2010-08-03 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition. Plos One, 5, 2010
5TXN	STRUCTURE OF Q151M MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), ... 著者 Das, K, Martinez, S.M, Arnold, E. 登録日 2016-11-17 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob. Agents Chemother., 61, 2017
1OCP	SOLUTION STRUCTURE OF OCT3 POU-HOMEODOMAIN 分子名称: OCT-3 著者 Morita, E.H, Hayashi, F, Shirakawa, M, Kyogoku, Y. 登録日 1995-02-21 公開日 1995-09-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the Oct-3 POU-Homeodomain in Solution, as Determined by Triple Resonance Heteronuclear Multidimensional NMR Spectroscopy Protein Sci., 4, 1995

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