7S4E

Crystal Structure of ligand ACBi1 in complex with bromodomain of human Smarca2 and pVHL:ElonginC:ElonginB complex

Summary for 7S4E

• Entry DOI: 10.2210/pdb7s4e/pdb
• Descriptor: Isoform Short of Probable global transcription activator SNF2L2, von Hippel-Lindau disease tumor suppressor, Elongin-C, ... (9 entities in total)
• Functional Keywords: complex, protac, degradation, assembly, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 114293.37

Authors

MacPherson, D.J.,Sherman, W. (deposition date: 2021-09-08, release date: 2022-10-05, Last modification date: 2023-10-25)

• Primary citation: Dixon, T.,MacPherson, D.,Mostofian, B.,Dauzhenka, T.,Lotz, S.,McGee, D.,Shechter, S.,Shrestha, U.R.,Wiewiora, R.,McDargh, Z.A.,Pei, F.,Pal, R.,Ribeiro, J.V.,Wilkerson, T.,Sachdeva, V.,Gao, N.,Jain, S.,Sparks, S.,Li, Y.,Vinitsky, A.,Zhang, X.,Razavi, A.M.,Kolossvary, I.,Imbriglio, J.,Evdokimov, A.,Bergeron, L.,Zhou, W.,Adhikari, J.,Ruprecht, B.,Dickson, A.,Xu, H.,Sherman, W.,Izaguirre, J.A.; Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry.; Nat Commun, 13:5884-5884, 2022; PubMed: 36202813; DOI: 10.1038/s41467-022-33575-4

Experimental method

X-RAY DIFFRACTION (2.25 Å)