7S4E
Crystal Structure of ligand ACBi1 in complex with bromodomain of human Smarca2 and pVHL:ElonginC:ElonginB complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Isoform Short of Probable global transcription activator SNF2L2 | polymer | 125 | 14420.5 | 2 | UniProt (P51531-2) Pfam (PF00439) UniProt (by SIFTS) (P51531) | Homo sapiens (Human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 2 | B, F (B, F) | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18702.3 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 3 | C, G (C, G) | Elongin-C | polymer | 96 | 10843.4 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 4 | D, H (D, H) | Elongin-B | polymer | 104 | 11748.4 | 2 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | AA, I, J, K, M... (G, A, B, D, F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 6 | L, Q, R, S, Y (A, B, F) | SODIUM ION | non-polymer | 23.0 | 5 | Chemie (NA) | |||
| 7 | N, P, W (B, F) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 8 | T, Z (B, F) | N-(1-fluorocyclopropane-1-carbonyl)-3-methyl-L-valyl-(4R)-N-{[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-4-hydroxy-L-prolinamide | non-polymer | 936.1 | 2 | Chemie (87A) | |||
| 9 | BA, CA, DA, EA, FA... (A, B, C, D, E...) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A, E: 1373 - 1493 (UniProt: P51531-2)
B, F: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Gly 1369 | - | expression tag |
| Ser 1370 | - | expression tag |
| Gly 1371 | - | expression tag |
| Gly 1372 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 111429.2 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2864.1 | |
| All* | Total formula weight | 114293.4 |
