3O96

Crystal Structure of Human AKT1 with an Allosteric Inhibitor

Summary for 3O96

• Entry DOI: 10.2210/pdb3o96/pdb
• Descriptor: RAC-alpha serine/threonine-protein kinase, 1-(1-(4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one (3 entities in total)
• Functional Keywords: pleckstrin homology, protein kinase, allosteric inhibitor, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P31749
• Total number of polymer chains: 1
• Total formula weight: 52414.73

Authors

Voegtli, W.C.,Wu, W.-I.,Lord-Ondash, H.A.,Dizon, F.P.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-08-03, release date: 2010-10-13, Last modification date: 2023-09-06)

• Primary citation: Wu, W.I.,Voegtli, W.C.,Sturgis, H.L.,Dizon, F.P.,Vigers, G.P.,Brandhuber, B.J.; Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition.; Plos One, 5:12913-12913, 2010; PubMed: 20886116; DOI: 10.1371/journal.pone.0012913

Experimental method

X-RAY DIFFRACTION (2.7 Å)