3O96
Crystal Structure of Human AKT1 with an Allosteric Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | RAC-alpha serine/threonine-protein kinase | polymer | 446 | 51863.1 | 1 | UniProt (P31749) Pfam (PF00169) Pfam (PF00069) Pfam (PF00433) In PDB | Homo sapiens (human) | RAC-PK-alpha, Protein kinase B, PKB, Proto-oncogene c-Akt |
| 2 | A | 1-(1-(4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | non-polymer | 551.6 | 1 | Chemie (IQO) | |||
| 3 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 2 - 443 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51863.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 551.6 | |
| All* | Total formula weight | 52414.7 |
