8BI7
Binary structure of 14-3-3s and PKR phosphopeptide
Summary for 8BI7
Entry DOI | 10.2210/pdb8bi7/pdb |
Descriptor | 14-3-3 protein sigma, PKR phosphopeptide, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | 14-3-3, hub-protein, phosphopeptide, peptide binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 28052.60 |
Authors | Somsen, B.A.,Ottmann, C. (deposition date: 2022-11-01, release date: 2023-03-29, Last modification date: 2024-02-07) |
Primary citation | Somsen, B.A.,Schellekens, R.J.C.,Verhoef, C.J.A.,Arkin, M.R.,Ottmann, C.,Cossar, P.J.,Brunsveld, L. Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145:6741-6752, 2023 Cited by PubMed: 36926879DOI: 10.1021/jacs.2c12781 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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