PDB: 1828 件ウェブページステータス検索Chemie searchBIRD

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3RVF	FXR with SRC1 and GSK2034 分子名称: 5-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1H-indole-2-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... 著者 Williams, S.P, Madauss, K.P. 登録日 2011-05-06 公開日 2011-09-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. Bioorg.Med.Chem.Lett., 21, 2011
3RUU	FXR with SRC1 and GSK237 分子名称: 6-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1H-indole-3-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... 著者 Williams, S.P, Madauss, K.P. 登録日 2011-05-05 公開日 2011-09-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. Bioorg.Med.Chem.Lett., 21, 2011
3RUT	FXR with SRC1 and GSK359 分子名称: 6-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1-benzothiophene-3-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... 著者 Williams, S.P, Madauss, K.P. 登録日 2011-05-05 公開日 2011-09-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. Bioorg.Med.Chem.Lett., 21, 2011
2YHD	Human androgen receptor in complex with AF2 small molecule inhibitor 分子名称: 4-(2,3-dihydro-1H-perimidin-2-yl)benzene-1,2-diol, ANDROGEN RECEPTOR, SULFATE ION, ... 著者 AxerioCilies, P, Lack, N.A, ShashiNayana, M.R, Chan, K.H, Yeung, A, LeBlanc, E, Guns, E, Rennie, P, Cherkasov, A. 登録日 2011-04-28 公開日 2011-09-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Inhibitors of Androgen Receptor Activation Function-2 (Af2) Site Identified Through Virtual Screening. J.Med.Chem., 54, 2011
3RLL	Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide 分子名称: (2S)-3-[(4-cyanonaphthalen-1-yl)oxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, Androgen receptor 著者 Bohl, C.E, Duke, C.B, Jones, A, Dalton, J.T, Miller, D.D. 登録日 2011-04-19 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J.Med.Chem., 54, 2011
3RLJ	Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-22 分子名称: (2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, Androgen receptor 著者 Bohl, C.E, Duke, C.B, Jones, A, Dalton, J.T, Miller, D.D. 登録日 2011-04-19 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J.Med.Chem., 54, 2011
2YFE	Ligand binding domain of human PPAR gamma in complex with amorfrutin 1 分子名称: Amorfrutin 1, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA 著者 de Groot, J.C, Buessow, K. 登録日 2011-04-05 公開日 2012-04-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Amorfrutins are Potent Antidiabetic Dietary Natural Products Proc.Natl.Acad.Sci.USA, 109, 2012
3AX8	Crystal structure of the human vitamin D receptor ligand binding domain complexed with 15alpha-methoxy-1alpha,25-dihydroxyvitamin D3 分子名称: (1R,3S,5Z)-5-[(2E)-2-[(1R,3S,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-3-methoxy-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, Vitamin D3 receptor 著者 Kakuda, S, Takimoto-Kamimura, M. 登録日 2011-03-30 公開日 2011-10-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 New C15-substituted active vitamin D3 Org.Lett., 13, 2011
3R8I	Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86) 分子名称: 2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl}phenoxy)-2-methylpropanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Loiodice, F, Laghezza, A, Fracchiolla, G, Lavecchia, A, Novellino, E, Crestani, M. 登録日 2011-03-24 公開日 2012-01-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. J.Med.Chem., 55, 2012
3R8A	X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity 分子名称: 2-ethyl-5,7-dimethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3H-imidazo[4,5-b]pyridine, Peroxisome proliferator-activated receptor gamma 著者 Ohren, J.F. 登録日 2011-03-23 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-gamma. J.Med.Chem., 54, 2011
3R8D	Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721 分子名称: 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE, Nuclear receptor subfamily 1 group I member 2 著者 Cheng, Y, Redinbo, M.R. 登録日 2011-03-23 公開日 2011-08-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci., 20, 2011
3R5N	Crystal structure of PPARgammaLBD complexed with the agonist magnolol 分子名称: 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Peroxisome proliferator-activated receptor gamma 著者 Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X. 登録日 2011-03-18 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). Plos One, 6, 2011
3R5M	Crystal structure of RXRalphaLBD complexed with the agonist magnolol 分子名称: 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X. 登録日 2011-03-18 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). Plos One, 6, 2011
3R2A	Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein 分子名称: 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, Nuclear receptor corepressor 2, Retinoic acid receptor RXR-alpha 著者 Zhang, H, Chen, L, Chen, J, Jiang, H, Shen, X. 登録日 2011-03-14 公開日 2011-05-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for retinoic x receptor repression on the tetramer. J.Biol.Chem., 286, 2011
3R29	Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 分子名称: Nuclear receptor corepressor 2, Retinoic acid receptor RXR-alpha 著者 Zhang, H, Chen, L, Chen, J, Jiang, H, Shen, X. 登録日 2011-03-14 公開日 2011-05-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for retinoic x receptor repression on the tetramer. J.Biol.Chem., 286, 2011
2YAT	Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex 分子名称: ESTRADIOL-PYRIDINIUM TETRAACETIC ACID, ESTROGEN RECEPTOR, EUROPIUM ION, ... 著者 Li, M.J, Greenblatt, H.M, Dym, O, Albeck, S, Degani, H, Sussman, J.L. 登録日 2011-02-24 公開日 2011-06-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators. J.Med.Chem., 54, 2011
3QT0	Revealing a steroid receptor ligand as a unique PPARgamma agonist 分子名称: 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, Nuclear receptor coactivator 1 peptide, Peroxisome proliferator-activated receptor gamma 著者 Rong, H. 登録日 2011-02-22 公開日 2012-02-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.496 Å) 主引用文献 Revealing a steroid receptor ligand as a unique PPAR gamma agonist. Cell Res., 22, 2012
3AUQ	Crystal structure of the human vitamin D receptor ligand binding domain complexed with Yne-diene type analog of active 14-epi-2alpha-methyl-19-norvitamin D3 分子名称: (1R,2S,3R)-5-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethynyl]-2-methyl-cyclohex-4-ene-1,3-diol, Vitamin D3 receptor 著者 Kakuda, S, Takimoto-Kamimura, M. 登録日 2011-02-15 公開日 2011-09-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Development of 14-epi-19-nortachysterol and its unprecedented binding configuration for the human vitamin D receptor J.Am.Chem.Soc., 133, 2011
3AUR	Crystal structure of the human vitamin D receptor ligand binding domain complexed with Yne-diene type analog of active 14-epi-2beta-methyl-19-norvitamin D3 分子名称: (1R,2S,3R)-5-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethynyl]-2-methyl-cyclohex-4-ene-1,3-diol, Vitamin D3 receptor 著者 Kakuda, S, Takimoto-Kamimura, M. 登録日 2011-02-15 公開日 2011-09-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Development of 14-epi-19-nortachysterol and its unprecedented binding configuration for the human vitamin D receptor J.Am.Chem.Soc., 133, 2011
3AUN	Crystal structure of the rat vitamin D receptor ligand binding domain complexed with YR335 and a synthetic peptide containing the NR2 box of DRIP 205 分子名称: (2R)-2-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}butane-1,4-diol, DRIP 205 NR2 box peptide, Vitamin D3 receptor 著者 Kakuda, S, Takimoto-Kamimura, M. 登録日 2011-02-10 公開日 2012-02-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands Bioorg.Med.Chem.Lett., 21, 2011
3Q95	Crystal structure of human estrogen receptor alpha LBD in complex with GRIP peptide and estriol 分子名称: CHLORIDE ION, ESTRIOL, Estrogen receptor, ... 著者 Rajan, S.S, Kim, Y, Vanek, K, Joachimiak, A, Greene, G.L. 登録日 2011-01-07 公開日 2012-01-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of human estrogen receptor alpha LBD in complex with GRIP peptide and Estriol TO BE PUBLISHED
3PO9	Crystal structure of PPARgamma ligand binding domain in complex with tripropyltin 分子名称: 1-[chloro(dipropyl)-lambda~4~-sulfanyl]propane, Peroxisome proliferator-activated receptor gamma, S-1,2-PROPANEDIOL 著者 le Maire, A, Bourguet, W. 登録日 2010-11-22 公開日 2011-11-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of PPARgamma ligand binding domain in complex with tripropyltin To be Published
2XYW	Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy 分子名称: 3-CHLORO-6-FLUORO-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, octyl beta-D-glucopyranoside 著者 Marquette, J.-P, Mathieu, M. 登録日 2010-11-19 公開日 2011-02-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6, 2011
2XYX	Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy 分子名称: 4-[2-[[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]AMINO]ETHYL]-N-(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)BENZENESULFONAMIDE, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, octyl beta-D-glucopyranoside 著者 Marquette, J.-P, Mathieu, M. 登録日 2010-11-19 公開日 2011-02-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6, 2011
2XYJ	Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy 分子名称: 5-CHLORO-2-METHOXY-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]BENZAMIDE, PENTAETHYLENE GLYCOL, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA 著者 Marquette, J.-P, Mathieu, M. 登録日 2010-11-18 公開日 2011-02-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6, 2011

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