3AUR

Crystal structure of the human vitamin D receptor ligand binding domain complexed with Yne-diene type analog of active 14-epi-2beta-methyl-19-norvitamin D3

Summary for 3AUR

Entry DOI	10.2210/pdb3aur/pdb
Related	3AUQ
Descriptor	Vitamin D3 receptor, (1R,2S,3R)-5-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethynyl]-2-methyl-cyclohex-4-ene-1,3-diol (3 entities in total)
Functional Keywords	hormone receptor, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P11473
Total number of polymer chains	1
Total formula weight	30219.96
Authors	Kakuda, S.,Takimoto-Kamimura, M. (deposition date: 2011-02-15, release date: 2011-09-14, Last modification date: 2023-11-01)
Primary citation	Sawada, D.,Tsukuda, Y.,Saito, H.,Kakuda, S.,Takimoto-Kamimura, M.,Ochiai, E.,Takenouchi, K.,Kittaka, A. Development of 14-epi-19-nortachysterol and its unprecedented binding configuration for the human vitamin D receptor J.Am.Chem.Soc., 133:7215-7221, 2011 Cited by PubMed: 21500802 DOI: 10.1021/ja201481j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation