2XYW

Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy

Summary for 2XYW

Entry DOI	10.2210/pdb2xyw/pdb
Related	1GWX 1Y0S 2AWH 2B50 2BAW 2GWX 2J14 2XYJ 2XYX 3GWX
Descriptor	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, 3-CHLORO-6-FLUORO-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE, octyl beta-D-glucopyranoside (3 entities in total)
Functional Keywords	dna-binding, transcription, transcription regulation, receptor, activator, zinc-finger
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	67655.36
Authors	Marquette, J.-P.,Mathieu, M. (deposition date: 2010-11-19, release date: 2011-02-23, Last modification date: 2020-07-29)
Primary citation	Keil, S.,Matter, H.,Schonafinger, K.,Glien, M.,Mathieu, M.,Marquette, J.-P.,Michot, N.,Haag-Diergarten, S.,Urmann, M.,Wendler, W. Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6:633-, 2011 Cited by PubMed: 21400663 DOI: 10.1002/CMDC.201100047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.14 Å)

Structure validation