2XYX

Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy

Summary for 2XYX

• Entry DOI: 10.2210/pdb2xyx/pdb
• Related: 1GWX 1Y0S 2AWH 2B50 2BAW 2GWX 2J14 2XYJ 2XYW 3GWX
• Descriptor: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, 4-[2-[[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]AMINO]ETHYL]-N-(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)BENZENESULFONAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: dna-binding, transcription, transcription regulation, receptor, activator, zinc-finger
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 67589.16

Authors

Marquette, J.-P.,Mathieu, M. (deposition date: 2010-11-19, release date: 2011-02-23, Last modification date: 2024-05-01)

• Primary citation: Keil, S.,Matter, H.,Schonafinger, K.,Glien, M.,Mathieu, M.,Marquette, J.-P.,Michot, N.,Haag-Diergarten, S.,Urmann, M.,Wendler, W.; Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy; Chemmedchem, 6:633-, 2011; PubMed: 21400663; DOI: 10.1002/CMDC.201100047

Experimental method

X-RAY DIFFRACTION (2.7 Å)