PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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4BUW	Crystal structure of human tankyrase 2 in complex with 2-(4-(2-oxo-1, 3-oxazolidin-3-yl)phenyl)-3,4-dihydroquinazolin-4-one 分子名称: 2-[4-(2-OXO-1,3-OXAZOLIDIN-3-YL)PHENYL]-3,4-DIHYDROQUINAZOLIN-4-ONE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Haikarainen, T, Narwal, M, Lehtio, L. 登録日 2013-06-24 公開日 2013-10-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors. Chemmedchem, 8, 2013
4BTF	Structure of MLKL 分子名称: 1,2-ETHANEDIOL, FORMIC ACID, MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN 著者 Czabotar, P.E, Murphy, J.M. 登録日 2013-06-16 公開日 2013-09-18 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.604 Å) 主引用文献 The Pseudokinase Mlkl Mediates Necroptosis Via a Molecular Switch Mechanism Immunity, 39, 2013
6B46	Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex with bound anti-CRISPR protein AcrF1 分子名称: Anti-CRISPR protein AcrF1, CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy3, ... 著者 Guo, T.W, Bartesaghi, A, Yang, H, Falconieri, V, Rao, P, Merk, A, Fox, T, Earl, L, Patel, D.J, Subramaniam, S. 登録日 2017-09-25 公開日 2017-10-18 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex. Cell, 171, 2017
4EER	Crystal structure of LOV2 domain of Arabidopsis thaliana phototropin 2 C426A mutant 分子名称: FLAVIN MONONUCLEOTIDE, Phototropin-2 著者 Hitomi, K, Christie, J.M, Arvai, A.S, Hartfield, K.A, Pratt, A.J, Tainer, J.A, Getzoff, E.D. 登録日 2012-03-28 公開日 2012-05-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.753 Å) 主引用文献 Structural Tuning of the Fluorescent Protein iLOV for Improved Photostability. J.Biol.Chem., 287, 2012
7BLC	BAZ2A bromodomain in complex with compound UP39 分子名称: Bromodomain adjacent to zinc finger domain protein 2A, methyl 5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]-2-(2-piperazin-1-ylethoxy)benzoate 著者 Dalle Vedove, A, Cazzanelli, G, Caflisch, A, Lolli, G. 登録日 2021-01-18 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Chemical probes in the BAZ2A bromodomain to be published
4EH7	Human p38 MAP kinase in complex with NP-F6 and RL87 分子名称: (3-phenoxyphenyl)methanol, Mitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine 著者 Over, B, Gruetter, C, Waldmann, H, Rauh, D. 登録日 2012-04-02 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem, 5, 2012
7BL8	BAZ2A bromodomain in complex with the chemical probe BAZ2-ICR 分子名称: 4-[5-(1-methylpyrazol-4-yl)-3-[2-(1-methylpyrazol-4-yl)ethyl]imidazol-4-yl]benzenecarbonitrile, Bromodomain adjacent to zinc finger domain protein 2A 著者 Dalle Vedove, A, Cazzanelli, G, Caflisch, A, Lolli, G. 登録日 2021-01-18 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Chemical probes in the BAZ2A bromodomain to be published
7BLB	BAZ2A bromodomain in complex with GSK4027 chemical probe 分子名称: 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one, Bromodomain adjacent to zinc finger domain protein 2A 著者 Dalle Vedove, A, Cazzanelli, G, Caflisch, A, Lolli, G. 登録日 2021-01-18 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Chemical probes in the BAZ2A bromodomain to be published
6G4W	Cryo-EM structure of a late human pre-40S ribosomal subunit - State A 分子名称: 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S13, ... 著者 Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2018-03-28 公開日 2018-06-06 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
7LUP	Human TRiC/CCT complex with reovirus outer capsid protein sigma-3 分子名称: Outer capsid protein sigma-3, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... 著者 Knowlton, J.J, Gestaut, D, Ma, B, Taylor, G, Seven, A.B, Leitner, A, Wilson, G.J, Shanker, S, Yates, N.A, Prasad, B.V.V, Aebersold, R, Chiu, W, Frydman, J, Dermody, T.S. 登録日 2021-02-22 公開日 2021-03-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (6.2 Å) 主引用文献 Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network. Proc.Natl.Acad.Sci.USA, 118, 2021
7LUM	Human TRiC in ATP/AlFx closed state 分子名称: T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... 著者 Knowlton, J.J, Gestaut, D, Ma, B, Taylor, G, Seven, A.B, Leitner, A, Wilson, G.J, Shanker, S, Yates, N.A, Prasad, B.V.V, Aebersold, R, Chiu, W, Frydman, J, Dermody, T.S. 登録日 2021-02-22 公開日 2021-03-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network. Proc.Natl.Acad.Sci.USA, 118, 2021
2Q2Z	Crystal Structure of KSP in Complex with Inhibitor 22 分子名称: 1-[(4R)-4-[3-(4-ACETYLPIPERAZIN-1-YL)PROPYL]-1-(2-FLUORO-5-METHYLPHENYL)-4-PHENYL-4,5-DIHYDRO-1H-PYRAZOL-3-YL]ETHANONE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... 著者 Yan, Y. 登録日 2007-05-29 公開日 2007-09-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 17, 2007
5ALC	Ticagrelor antidote candidate Fab 72 in complex with ticagrelor 分子名称: ANTI-TICAGRELOR FAB 72, HEAVY CHAIN, LIGHT CHAIN, ... 著者 Buchanan, A, Newton, P, Pehrsson, S, Inghardt, T, Antonsson, T, Svensson, P, Sjogren, T, Oster, L, Janefeldt, A, Sandinge, A, Keyes, F, Austin, M, Spooner, J, Penney, M, Howells, G, Vaughan, T, Nylander, S. 登録日 2015-03-07 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and Functional Characterisation of a Specific Antidote for Ticagrelor. Blood, 125, 2015
6G51	Cryo-EM structure of a late human pre-40S ribosomal subunit - State D 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2018-03-28 公開日 2018-06-06 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
6JSJ	Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1 分子名称: Dynamin-like GTPase MGM1, mitochondrial, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Yan, L, Li, L. 登録日 2019-04-08 公開日 2020-02-19 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1. Proc.Natl.Acad.Sci.USA, 117, 2020
2ELB	Crystal Structure of the BAR-PH domain of human APPL1 分子名称: Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 著者 Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. 登録日 2007-03-27 公開日 2007-05-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure, 15, 2007
4DZP	Crystal structure of the terminase small subunit gp1 with R48A mutation of the bacterial virus sf6 分子名称: Gene 1 protein 著者 Zhao, H, Tang, L. 登録日 2012-03-01 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and Functional Studies of the Phage Sf6 Terminase Small Subunit Reveal a DNA-Spooling Device Facilitated by Structural Plasticity. J.Mol.Biol., 423, 2012
2E29	Solution structure of the GUCT domain from human ATP-dependent RNA helicase DDX50, DEAD box protein 50 分子名称: ATP-dependent RNA helicase DDX50 著者 Ohnishi, S, Paakkonen, K, Guntert, P, Sato, M, Koshiba, S, Harada, T, Watanabe, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-11-10 公開日 2007-05-15 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the GUCT domain from human RNA helicase II/Gubeta reveals the RRM fold, but implausible RNA interactions Proteins, 74, 2008
6K3Z	Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM) 分子名称: CRISPR-associated endonuclease Cas9, DNA (28-MER), DNA (5'-D(*AP*AP*AP*TP*GP*AP*TP*AP*TP*TP*G)-3'), ... 著者 Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. 登録日 2019-05-22 公開日 2019-09-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
6K4P	Crystal structure of xCas9 in complex with sgRNA and DNA (TGG PAM) 分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), PHOSPHATE ION, ... 著者 Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. 登録日 2019-05-25 公開日 2019-09-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
6K5T	Complex of SUMO1 and phosphorylated hcmv protein IE2 分子名称: 12-mer from Viral transcription factor IE2, Small ubiquitin-related modifier 1 著者 Tripathi, V, Chatterjee, K.S. 登録日 2019-05-31 公開日 2019-08-07 最終更新日 2019-12-25 実験手法 SOLUTION NMR 主引用文献 Casein kinase-2-mediated phosphorylation increases the SUMO-dependent activity of the cytomegalovirus transactivator IE2. J.Biol.Chem., 294, 2019
2P1L	Structure of the Bcl-XL:Beclin 1 complex 分子名称: Apoptosis regulator Bcl-X, Beclin 1 著者 Jeffrey, P.D, Shi, Y, Oberstein, A.L. 登録日 2007-03-05 公開日 2007-03-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein J.Biol.Chem., 282, 2007
4DLI	Human p38 MAP kinase in complex with RL87 分子名称: Mitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine 著者 Gruetter, C, Getlik, M, Simard, J.R, Rauh, D. 登録日 2012-02-06 公開日 2013-01-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38alpha kinase. Plos One, 7, 2012
6IHJ	Crystal structure of Drosophila Nxf1 NTF2 domain in complex with Nxt1/p15 分子名称: NTF2-related export protein, Nuclear RNA export factor 1 著者 Huang, Y, Yuan, X. 登録日 2018-09-30 公開日 2019-08-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation. Nat.Cell Biol., 21, 2019
4AVW	Crystal structure of human tankyrase 2 in complex with TIQ-A 分子名称: 4H-thieno[2,3-c]isoquinolin-5-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Haikarainen, T, Narwal, M, Lehtio, L. 登録日 2012-05-29 公開日 2012-06-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors Acs Med.Chem.Lett., 5, 2014

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