4AVW

Crystal structure of human tankyrase 2 in complex with TIQ-A

Summary for 4AVW

Entry DOI	10.2210/pdb4avw/pdb
Related	2Y0I 4AVU
Descriptor	TANKYRASE-2, 4H-thieno[2,3-c]isoquinolin-5-one, ZINC ION, ... (7 entities in total)
Functional Keywords	transferase, transferase inhibitor complex, protein-ligand complex, diphtheria toxin like fold, adp-ribosylation
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	55913.51
Authors	Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2012-05-29, release date: 2012-06-13, Last modification date: 2019-01-30)
Primary citation	Haikarainen, T.,Narwal, M.,Joensuu, P.,Lehtio, L. Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors Acs Med.Chem.Lett., 5:18-, 2014 Cited by PubMed: 24900770 DOI: 10.1021/ML400292S PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation