2Y0I

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)

Summary for 2Y0I

• Entry DOI: 10.2210/pdb2y0i/pdb
• Related: 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM
• Descriptor: HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, TANKYRASE-2, FE (II) ION, ... (7 entities in total)
• Functional Keywords: oxidoreductase-peptide complex, dioxygenase, helix-loop-helix-beta, facial triad, asparaginyl/aspartyl hydroxylase, ankyrin repeat domain, oxidoreductase/peptide
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus: Q9NWT6; Cytoplasm: Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 43611.50

Authors

Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-12-02, release date: 2011-02-02, Last modification date: 2023-12-20)

• Primary citation: Yang, M.,Chowdhury, R.,Ge, W.,Hamed, R.B.,McDonough, M.A.,Claridge, T.D.,Kessler, B.M.,Cockman, M.E.,Ratcliffe, P.J.,Schofield, C.J.; Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.; FEBS J., 278:1086-1097, 2011; PubMed: 21251231; DOI: 10.1111/j.1742-4658.2011.08022.x

Experimental method

X-RAY DIFFRACTION (2.28 Å)