2CGO
FACTOR INHIBITING HIF-1 ALPHA with fumarate
Summary for 2CGO
Entry DOI | 10.2210/pdb2cgo/pdb |
Related | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN |
Descriptor | HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (III) ION, FUMARIC ACID, ... (5 entities in total) |
Functional Keywords | oxidoreductase, 2-oxoglutarate, acetylation, activator, alternative splicing, asparaginyl hydroxylase, dna-binding, dsbh, fi, hif, hydroxylation, hypoxia, nuclear protein, oxygenase, phosphorylation, polymorphism, s-nitrosylation, transcription, transcription activator/inhibitor, transcription regulation, dioxygenase, iron, metal-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: Q9NWT6 |
Total number of polymer chains | 1 |
Total formula weight | 40884.45 |
Authors | McDonough, M.A.,Clifton, I.J.,Schofield, C.J. (deposition date: 2006-03-09, release date: 2006-12-13, Last modification date: 2023-12-13) |
Primary citation | Hewitson, K.,Lienard, B.,McDonough, M.A.,Clifton, I.J.,Butler, D.,Soares, A.S.,Oldham, N.J.,McNeill, L.A.,Schofield, C.J. Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem., 282:3293-3301, 2007 Cited by PubMed: 17135241DOI: 10.1074/JBC.M608337200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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