1H2N

Factor Inhibiting HIF-1 alpha

Summary for 1H2N

Related1H2K 1H2L 1H2M
DescriptorHYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total)
Functional Keywordstranscription activator, oxidoreductase, oxygenase, hypoxia, hydroxylase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus Q9NWT6
Total number of polymer chains1
Total molecular weight40818.41
Authors
Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Schlemminger, I.,Seibel, J.F.,Schofield, C.J. (deposition date: 2002-08-12, release date: 2002-11-28, Last modification date: 2018-02-21)
Primary citation
Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Seibel, J.F.,Schlemminger, I.,Pugh, C.,Ratcliffe, P.,Schofield, C.J.
Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278:1802-1806, 2003
PubMed: 12446723 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.C200644200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.84 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26270 2.8% 3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171313
PDB entries from 2020-11-18