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2W0X

FACTOR INHIBITING HIF-1 ALPHA WITH PYRIDINE 2,4 DICARBOXYLIC ACID

Summary for 2W0X
Entry DOI10.2210/pdb2w0x/pdb
Related1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2WA3 2WA4
DescriptorHYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ... (6 entities in total)
Functional Keywordshydroxylase, dioxygenase, transcription, oxidoreductase, transcription activator/inhibitor, hypoxia
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus: Q9NWT6
Total number of polymer chains1
Total formula weight40931.53
Authors
Conejo-Garcia, A.,Lienard, B.M.R.,Clifton, I.J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2008-10-10, release date: 2009-11-24, Last modification date: 2023-12-13)
Primary citationConejo-Garcia, A.,McDonough, M.A.,Loenarz, C.,McNeill, L.A.,Hewitson, K.S.,Ge, W.,Lienard, B.M.,Schofield, C.J.,Clifton, I.J.
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Bioorg. Med. Chem. Lett., 20:6125-6128, 2010
Cited by
PubMed: 20822901
DOI: 10.1016/j.bmcl.2010.08.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.12 Å)
Structure validation

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