5ALC

Ticagrelor antidote candidate Fab 72 in complex with ticagrelor

Summary for 5ALC

• Entry DOI: 10.2210/pdb5alc/pdb
• Related: 5ALB
• Descriptor: ANTI-TICAGRELOR FAB 72, HEAVY CHAIN, ANTI-TICAGRELOR FAB 72, LIGHT CHAIN, Ticagrelor, ... (4 entities in total)
• Functional Keywords: immune system, antibody fragment, antidote, drug
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 47823.10

Authors

Buchanan, A.,Newton, P.,Pehrsson, S.,Inghardt, T.,Antonsson, T.,Svensson, P.,Sjogren, T.,Oster, L.,Janefeldt, A.,Sandinge, A.,Keyes, F.,Austin, M.,Spooner, J.,Penney, M.,Howells, G.,Vaughan, T.,Nylander, S. (deposition date: 2015-03-07, release date: 2015-04-01, Last modification date: 2024-01-10)

• Primary citation: Buchanan, A.,Newton, P.,Pehrsson, S.,Inghardt, T.,Antonsson, T.,Svensson, P.,Sjogren, T.,Oster, L.,Janefeldt, A.,Sandinge, A.,Keyes, F.,Austin, M.,Spooner, J.,Gennemark, P.,Penney, M.,Howells, G.,Vaughan, T.,Nylander, S.; Structural and Functional Characterisation of a Specific Antidote for Ticagrelor.; Blood, 125:3484-, 2015; PubMed: 25788700; DOI: 10.1182/BLOOD-2015-01-622928

Experimental method

X-RAY DIFFRACTION (1.7 Å)