8CE0
 
 | | N-terminal domain of human apolipoprotein E | | 分子名称: | GLYCEROL, Maltodextrin-binding protein,Apolipoprotein E | | 著者 | Marek, M, Nemergut, M. | | 登録日 | 2023-02-01 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18, 2023
|
|
8CDY
 | | N-terminal domain of human apolipoprotein E | | 分子名称: | Maltodextrin-binding protein,Apolipoprotein E | | 著者 | Marek, M, Nemergut, M. | | 登録日 | 2023-02-01 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18, 2023
|
|
6LNM
 | |
6KMH
 | | The crystal structure of CASK/Mint1 complex | | 分子名称: | Amyloid-beta A4 precursor protein-binding family A member 1, CHLORIDE ION, IODIDE ION, ... | | 著者 | Li, W, Feng, W. | | 登録日 | 2019-07-31 | | 公開日 | 2020-08-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion.
Cell Discov, 6, 2020
|
|
7XSJ
 | | The structure of the Mint1/Munc18-1/syntaxin-1 complex | | 分子名称: | Amyloid-beta A4 precursor protein-binding family A member 1, Syntaxin-1A, Syntaxin-binding protein 1 | | 著者 | Feng, W, Li, W. | | 登録日 | 2022-05-14 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex.
Structure, 31, 2023
|
|
2Y3J
 | | Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35) | | 分子名称: | AMYLOID BETA A4 PROTEIN | | 著者 | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | 登録日 | 2010-12-21 | | 公開日 | 2011-11-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
2Y2A
 | | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I | | 分子名称: | ACETATE ION, AMYLOID BETA A4 PROTEIN | | 著者 | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | 登録日 | 2010-12-14 | | 公開日 | 2011-10-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
2Y29
 | | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III | | 分子名称: | AMYLOID BETA A4 PROTEIN | | 著者 | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | 登録日 | 2010-12-14 | | 公開日 | 2011-10-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
6RHY
 | |
5W3P
 | | ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16 | | 分子名称: | Amyloid beta A4 protein, Antibody C706 Fab HEAVY CHAIN, Antibody C706 Fab LIGHT CHAIN, ... | | 著者 | Teplyakov, A, Obmolova, G, Gilliland, G.L. | | 登録日 | 2017-06-08 | | 公開日 | 2017-09-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | A coiled conformation of amyloid-beta recognized by antibody C706.
Alzheimers Res Ther, 9, 2017
|
|
5HQ3
 | | Stable, high-expression variant of human acetylcholinesterase | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP | | 著者 | Goldenzweig, A, Goldsmith, M, Hill, S.E, Gertman, O, Laurino, P, Ashani, Y, Dym, O, Albeck, S, Unger, T, Prilusky, J, Lieberman, R.L, Aharoni, A, Silman, I, Sussman, J.L, Tawfik, D.S, Fleishman, S.J. | | 登録日 | 2016-01-21 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.
Mol.Cell, 63, 2016
|
|
3SV1
 | | Crystal structure of APP peptide bound rat Mint2 PARM | | 分子名称: | Amyloid beta A4 precursor protein-binding family A member 2, Amyloid beta A4 protein | | 著者 | Shen, Y, Long, J, Yan, X, Xie, X. | | 登録日 | 2011-07-12 | | 公開日 | 2012-07-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Open-closed motion of Mint2 regulates APP metabolism
J Mol Cell Biol, 5, 2013
|
|
6O69
 | |
3SUZ
 | |
1B41
 | | HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... | | 著者 | Kryger, G, Harel, M, Shafferman, A, Silman, I, Sussman, J.L. | | 登録日 | 1999-01-05 | | 公開日 | 2001-01-17 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta Crystallogr.,Sect.D, 56, 2000
|
|
2WK3
 | |
5MYK
 | |
5MYO
 | | Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb | | 分子名称: | Amyloid beta A4 protein, Fab c#6 heavy chain, Fab c#6 light chain, ... | | 著者 | Parthier, C, Piechotta, A, Stubbs, M.T. | | 登録日 | 2017-01-27 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
|
|
2M38
 | | PTB domain of AIDA1 | | 分子名称: | Ankyrin repeat and sterile alpha motif domain-containing protein 1B | | 著者 | Donaldson, L. | | 登録日 | 2013-01-14 | | 公開日 | 2013-01-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein.
Plos One, 8, 2013
|
|
1HZ3
 | | ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35) | | 分子名称: | A-BETA AMYLOID | | 著者 | Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P. | | 登録日 | 2001-01-23 | | 公開日 | 2001-01-31 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
J.Struct.Biol., 130, 2000
|
|
7WVY
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | | 分子名称: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
|
|
2BP4
 | | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution | | 分子名称: | AMYLOID BETA A4 PROTEIN | | 著者 | Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S. | | 登録日 | 2005-04-18 | | 公開日 | 2005-04-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Changes of Region 1-16 of the Alzheimer Disease Amyloid Beta-Peptide Upon Zinc Binding and in Vitro Aging.
J.Biol.Chem., 281, 2006
|
|
8IM7
 | | Human gamma-secretase treated with ganglioside GM1 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhou, R, Yang, G, Shi, Y. | | 登録日 | 2023-03-06 | | 公開日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease.
Adv Sci, 10, 2023
|
|
2IDH
 | |
5FN3
 | | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
|
|
