PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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5GJI	PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ... 著者 Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. 登録日 2016-06-30 公開日 2016-12-14 最終更新日 2017-05-10 実験手法 X-RAY DIFFRACTION (0.9 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
5GJH	Gads SH2 domain/CD28-derived peptide complex 分子名称: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28 著者 Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. 登録日 2016-06-30 公開日 2016-12-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
8ATK	The SH2 domain of mouse SH2B1 分子名称: SH2B adapter protein 1 著者 Fowler, N.J, Williamson, M.P, Albalwi, M.F. 登録日 2022-08-23 公開日 2023-05-24 最終更新日 2023-08-16 実験手法 SOLUTION NMR 主引用文献 Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1. Structure, 31, 2023
5TNW	Phospholipase C gamma-1 C-terminal SH2 domain 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Wuttke, D.S, McKercher, M.A. 登録日 2016-10-14 公開日 2017-04-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TO4	Phospholipase C gamma-1 C-terminal SH2 domain, spacegroup P212121 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Wuttke, D.S, McKercher, M.A. 登録日 2016-10-16 公開日 2017-04-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5CDW	Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide 分子名称: Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN 著者 Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. 登録日 2015-07-05 公開日 2016-05-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25, 2016
5TQ1	Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Insulin receptor 著者 Wuttke, D.S, McKercher, M.A. 登録日 2016-10-21 公開日 2017-04-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.485 Å) 主引用文献 Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TQS	Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Receptor protein-tyrosine kinase 著者 Wuttke, D.S, McKercher, M.A. 登録日 2016-10-24 公開日 2017-04-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.876 Å) 主引用文献 Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2014-04-06 公開日 2014-06-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
5U1Q	Grb7-SH2 with bicyclic peptide inhibitor 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST 著者 Watson, G.M, Wilce, M.C.J, Wilce, J.A. 登録日 2016-11-28 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
5D0J	Grb7 SH2 with inhibitor peptide 分子名称: G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. 登録日 2015-08-03 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5DF6	Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide 分子名称: Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip 著者 Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2015-08-26 公開日 2015-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
5TYI	Grb7 SH2 with bicyclic peptide containing pY mimetic 分子名称: Growth factor receptor-bound protein 7, Peptide inhibitor 著者 Watson, G.M, Wilce, M.C.J, Wilce, J.A. 登録日 2016-11-20 公開日 2017-11-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
4P9V	Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2 著者 Clements, J.H, Martin, S.F. 登録日 2014-04-06 公開日 2014-06-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
5U06	Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic 分子名称: Growth factor receptor-bound protein 7, POTASSIUM ION, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST 著者 Watson, G.M, Wilce, J.A. 登録日 2016-11-22 公開日 2017-11-15 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
5VKO	SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493 分子名称: DNA-directed RNA polymerase II subunit RPB1, ISOPROPYL ALCOHOL, Transcription elongation factor SPT6 著者 Sdano, M.A, Whitby, F.G, Hill, C.P. 登録日 2017-04-21 公開日 2017-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
5W3R	SH2B1 SH2 Domain 分子名称: PHENOL, PHOSPHATE ION, SH2B adapter protein 1 著者 McKercher, M.A, Wuttke, D.S. 登録日 2017-06-08 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.386 Å) 主引用文献 Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins, 86, 2018
5EEQ	Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5EEL	Grb7 SH2 with bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... 著者 Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2018-12-26 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5VKL	SPT6 tSH2-RPB1 1476-1500 pS1493 分子名称: DNA-directed RNA polymerase II subunit RPB1, Transcription elongation factor SPT6 著者 Sdano, M.A, Whitby, F.G, Hill, C.P. 登録日 2017-04-21 公開日 2017-10-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
4QSY	SHP2 SH2 domain in complex with GAB1 peptide 分子名称: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 著者 Gogl, G, Remenyi, A. 登録日 2014-07-06 公開日 2015-07-08 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
4ROJ	Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide 分子名称: Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION 著者 Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2014-10-28 公開日 2014-12-10 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide TO BE PUBLISHED
1SPS	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS 分子名称: PEPTIDE YEEI, SRC SH2 DOMAIN 著者 Waksman, G, Kuriyan, J. 登録日 1993-03-05 公開日 1994-05-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1SKJ	COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX 分子名称: 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN 著者 Holland, D.R, Rubin, J.R. 登録日 1997-09-18 公開日 1998-02-25 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997
1SPR	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS 分子名称: PHOSPHATE ION, SRC TYROSINE KINASE SH2 DOMAIN 著者 Waksman, G, Kuriyan, J. 登録日 1993-03-05 公開日 1994-05-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993

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