5DF6

Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide

Replaces:  5C96

Summary for 5DF6

• Entry DOI: 10.2210/pdb5df6/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, txnip, UNKNOWN ATOM OR ION, ... (4 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q06124
• Total number of polymer chains: 3
• Total formula weight: 31757.37

Authors

Dong, A.,Li, W.,Tempel, W.,Liu, Y.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2015-08-26, release date: 2015-09-23, Last modification date: 2023-11-15)

• Primary citation: Liu, Y.,Lau, J.,Li, W.,Tempel, W.,Li, L.,Dong, A.,Narula, A.,Qin, S.,Min, J.; Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.; Biochem.J., 473:179-187, 2016; PubMed: 26527736; DOI: 10.1042/BJ20150830

Experimental method

X-RAY DIFFRACTION (1.78 Å)