5DF6

Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide

Replaces:  5C96

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein phosphatase non-receptor type 11	polymer	255	28750.1	1	UniProt (Q06124) Pfam (PF00017) In PDB	Homo sapiens (Human)	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3
2	B, C	txnip	polymer	13	1503.6	2	UniProt (by SIFTS) (Q9H3M7) In PDB	Homo sapiens
3	A, B	UNKNOWN ATOM OR ION	non-polymer			7	Chemie (UNX)
4		water	water		18.0	110	Chemie (HOH)

Sequence modifications

A: 1 - 222 (UniProt: Q06124)

PDB	External Database	Details
Gly -27	-	expression tag
Ser -26	-	expression tag
Ser -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
Gly -16	-	expression tag
Arg -15	-	expression tag
Arg -14	-	expression tag
Ala -13	-	expression tag
Ser -12	-	expression tag
Val -11	-	expression tag
Glu -10	-	expression tag
Asn -9	-	expression tag
Leu -8	-	expression tag
Tyr -7	-	expression tag
Phe -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Arg -1	-	expression tag
Ala 0	-	expression tag
Leu 223	-	expression tag
Ile 224	-	expression tag
Asn 225	-	expression tag
Glu 226	-	expression tag
Phe 227	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	31757.4
Non-Polymers*	Number of molecules	7
	Total formula weight	0.0
All*	Total formula weight	31757.4

*Water molecules are not included.