PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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7RNU	nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 分子名称: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... 著者 Dai, S, Horton, J.R, Cheng, X. 登録日 2021-07-29 公開日 2021-08-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7R8X	Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide 分子名称: EPOR pY454 phosphopeptide, SH2B adapter protein 3 著者 Morris, R, Kershaw, N.J, Babon, J.J. 登録日 2021-06-27 公開日 2021-10-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide 分子名称: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 著者 Morris, R, Kershaw, N.J, Babon, J.J. 登録日 2021-06-27 公開日 2021-10-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
5D0J	Grb7 SH2 with inhibitor peptide 分子名称: G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. 登録日 2015-08-03 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
7SA7	Crystal structure of the apo SH2 domains of Syk 分子名称: Tyrosine-protein kinase SYK 著者 Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J. 登録日 2021-09-22 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci., 30, 2021
5DF6	Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide 分子名称: Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip 著者 Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2015-08-26 公開日 2015-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
5EEQ	Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5EEL	Grb7 SH2 with bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... 著者 Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2018-12-26 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
7T1K	Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1L	Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide 分子名称: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1U	Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide 分子名称: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION 著者 Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
4F59	Triple mutant Src SH2 domain 分子名称: Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4FBN	Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. 登録日 2012-05-23 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
4EIH	Crystal structure of Arg SH2 domain 分子名称: Abelson tyrosine-protein kinase 2, CHLORIDE ION 著者 Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. 登録日 2012-04-05 公開日 2013-04-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
4F5A	Triple mutant Src SH2 domain bound to phosphate ion 分子名称: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F5B	Triple mutant Src SH2 domain bound to phosphotyrosine 分子名称: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4EY0	Structure of tandem SH2 domains from PLCgamma1 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. 登録日 2012-05-01 公開日 2012-10-31 最終更新日 2013-06-19 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
2QMS	Crystal structure of a signaling molecule 分子名称: Growth factor receptor-bound protein 7, SULFATE ION 著者 Porter, C.J, Wilce, M.C, Wilce, J.A. 登録日 2007-07-16 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation. Bmc Struct.Biol., 7, 2007
2RSY	Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp 分子名称: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK 著者 Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T. 登録日 2012-09-10 公開日 2013-04-10 最終更新日 2019-12-25 実験手法 SOLUTION NMR 主引用文献 Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains. J.Biol.Chem., 288, 2013
2RMX	Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A 分子名称: NKG2-A/NKG2-B type II integral membrane protein, Tyrosine-protein phosphatase non-receptor type 6 著者 Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-11-30 公開日 2008-12-02 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1 To be Published
2PNB	STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN 著者 Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D. 登録日 1992-06-30 公開日 1994-01-31 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase. Nature, 358, 1992
2PLE	NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE 分子名称: PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF 著者 Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D. 登録日 1994-08-19 公開日 1995-01-26 最終更新日 2017-11-29 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell(Cambridge,Mass.), 77, 1994
2PNA	STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN 著者 Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D. 登録日 1992-06-30 公開日 1994-01-31 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase. Nature, 358, 1992
2ROR	Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 分子名称: 15-meric peptide from Lymphocyte cytosolic protein 2, Proto-oncogene vav 著者 Tanaka, M, Kasai, T, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2008-04-08 公開日 2009-04-21 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 To be Published
2RVF	Solution NMR structure of Monosiga brevicollis CRK/CRKL homolog (crka1) SH2 domain 分子名称: Predicted protein 著者 Kasai, T, Pawlak, J, Imamoto, A, Kigawa, T. 登録日 2015-09-24 公開日 2016-09-21 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 A pre-metazoan origin of the CRK gene family and co-opted signaling network Sci Rep, 6, 2016

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