4FBN

Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains

Summary for 4FBN

Entry DOI	10.2210/pdb4fbn/pdb
Related	4EY0
Descriptor	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (2 entities in total)
Functional Keywords	sh2 domain, plcgamma specific array, interaction domain, fibroblast growth factor receptor 1, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell projection, lamellipodium: P19174
Total number of polymer chains	1
Total formula weight	28578.17
Authors	Cole, A.R.,Mas-Droux, C.P.,Bunney, T.D.,Katan, M. (deposition date: 2012-05-23, release date: 2012-10-31, Last modification date: 2024-02-28)
Primary citation	Bunney, T.D.,Esposito, D.,Mas-Droux, C.,Lamber, E.,Baxendale, R.W.,Martins, M.,Cole, A.,Svergun, D.,Driscoll, P.C.,Katan, M. Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20:2062-2075, 2012 Cited by PubMed: 23063561 DOI: 10.1016/j.str.2012.09.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation