4FBN
Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Domain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SYK","evidences":[{"source":"PubMed","id":"20494825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8657103","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15144186","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ITK, SYK and TXK","evidences":[{"source":"PubMed","id":"11564877","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15215251","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8657103","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
