PDB: 5470 件ウェブページステータス検索Chemie searchBIRD

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6A5L	RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome, with foreign DNA 分子名称: DNA (198-MER), DNA (42-MER), DNA-directed RNA polymerase subunit, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-06-24 公開日 2018-10-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
6A7U	Crystal structure of histone H2A.Bbd-H2B dimer 分子名称: Histone H2B type 2-E,Histone H2A-Bbd type 2/3 著者 Dai, L, Zhou, Z. 登録日 2018-07-04 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the histone heterodimer containing histone variant H2A.Bbd. Biochem. Biophys. Res. Commun., 503, 2018
6A5R	RNA polymerase II elongation complex stalled at SHL(-2) of the nucleosome 分子名称: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-06-25 公開日 2018-10-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (8.7 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
6A5O	RNA polymerase II elongation complex stalled at SHL(-6) of the nucleosome 分子名称: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-06-25 公開日 2018-10-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (9.9 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
5ZBX	The crystal structure of the nucleosome containing histone H3.1 CATD(V76Q, K77D) 分子名称: CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... 著者 Arimura, Y, Takagi, H, Kurumizaka, H. 登録日 2018-02-13 公開日 2019-02-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism. Nat Commun, 10, 2019
5ZEN	Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate 分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... 著者 Chen, S.F, Wang, Y.R, Chan, N.L. 登録日 2018-02-27 公開日 2018-08-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9, 2018
5Z57	Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ALANINE, BUD13 homolog, ... 著者 Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. 登録日 2018-01-17 公開日 2018-09-19 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
5Y0C	Crystal Structure of the human nucleosome at 2.09 angstrom resolution 分子名称: CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... 著者 Kurumizaka, H, Arimura, Y, Fujita, R, Noda, M. 登録日 2017-07-16 公開日 2018-07-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.087 Å) 主引用文献 Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
6B6U	Pyruvate Kinase M2 mutant - S437Y 分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Srivastava, D, Dey, M. 登録日 2017-10-03 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 56, 2017
5Z30	The crystal structure of the nucleosome containing a cancer-associated histone H2A.Z R80C mutant 分子名称: CHLORIDE ION, DNA (146-MER), Histone H2A.Z, ... 著者 Horikoshi, N, Arimura, Y, Kurumizaka, H. 登録日 2018-01-05 公開日 2018-07-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
5ZBZ	Crystal structure of the DEAD domain of Human eIF4A with sanguinarine 分子名称: 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium, Eukaryotic initiation factor 4A-I, MALONATE ION 著者 Ding, Y, Ding, L. 登録日 2018-02-14 公開日 2019-02-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.30860257 Å) 主引用文献 Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling. Cell Chem Biol, 26, 2019
5ZRF	Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, ... 著者 Chen, S.F, Wang, Y.R, Wu, C.C, Chan, N.L. 登録日 2018-04-24 公開日 2018-08-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9, 2018
6A5T	RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome 分子名称: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-06-25 公開日 2018-10-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
6BJC	TPX2_mini decorated GMPCPP-microtubule 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Zhang, R, Nogales, E. 登録日 2017-11-05 公開日 2017-11-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insight into TPX2-stimulated microtubule assembly. Elife, 6, 2017
6A5U	RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome, with foreign DNA, tilt conformation 分子名称: DNA (198-MER), DNA (40-MER), DNA-directed RNA polymerase subunit, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-06-25 公開日 2018-10-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (7.6 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
6A5P	RNA polymerase II elongation complex stalled at SHL(-5) of the nucleosome 分子名称: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-06-25 公開日 2018-10-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
6BM0	Cryo-EM structure of human CPSF-160-WDR33 complex at 3.8 A resolution 分子名称: Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 著者 Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. 登録日 2017-11-12 公開日 2017-11-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLY	Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution 分子名称: Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 著者 Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. 登録日 2017-11-12 公開日 2017-11-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6C23	Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, JARID2-substrate, ... 著者 Kasinath, V, Faini, M, Poepsel, S, Reif, D, Feng, A, Stjepanovic, G, Aebersold, R, Nogales, E. 登録日 2018-01-05 公開日 2018-01-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359, 2018
4DEA	Aurora A in complex with YL1-038-18 分子名称: 1,2-ETHANEDIOL, 4,4'-(pyrimidine-2,4-diyldiimino)dibenzoic acid, Aurora kinase A 著者 Martin, M.P, Zhu, J.-Y, Schonbrunn, E. 登録日 2012-01-20 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors. J.Med.Chem., 55, 2012
4DK8	Crystal structure of LXR ligand binding domain in complex with partial agonist 5 分子名称: ACETATE ION, CALCIUM ION, N-methyl-N-(4-{(1S)-2,2,2-trifluoro-1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]ethyl}phenyl)benzenesulfonamide, ... 著者 Piper, D.E, Kopecky, D.J, Xu, H. 登録日 2012-02-03 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Discovery of a new binding mode for a series of liver X receptor agonists. Bioorg.Med.Chem.Lett., 22, 2012
4DON	Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon 分子名称: 3-methyl-3,4-dihydroquinazolin-2(1H)-one, Bromodomain-containing protein 4 著者 Xiong, B, Cao, D.Y, Chen, W.Y, Chen, T.T, Xu, Y.C, Shen, J.K. 登録日 2012-02-09 公開日 2013-02-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon To be Published
4DGC	TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex 分子名称: TRIMCyp, cyclosporin A 著者 Caines, M.E.C, Bichel, K, Price, A.J, McEwan, W.A, James, L.C. 登録日 2012-01-25 公開日 2012-02-08 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Diverse HIV viruses are targeted by a conformationally dynamic antiviral. Nat.Struct.Mol.Biol., 19, 2012
4DEB	Aurora A in complex with RK2-17-01 分子名称: 1,2-ETHANEDIOL, 4-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]benzamide, Aurora kinase A 著者 Martin, M.P, Zhu, J.-Y, Schonbrunn, E. 登録日 2012-01-20 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors. J.Med.Chem., 55, 2012
4DGL	Crystal Structure of the CK2 Tetrameric Holoenzyme 分子名称: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION 著者 Lolli, G, Battistutta, R. 登録日 2012-01-26 公開日 2012-05-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization. Acs Chem.Biol., 7, 2012

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