5ZRF
Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21
Summary for 5ZRF
Entry DOI | 10.2210/pdb5zrf/pdb |
Descriptor | DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... (6 entities in total) |
Functional Keywords | type ii topoisomerase, anti-cancer drug, topoii cleavage complex, isomerase-dna complex, isomerase-dna-isomerase inhibitor complex, isomerase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 198128.89 |
Authors | Chen, S.F.,Wang, Y.R.,Wu, C.C.,Chan, N.L. (deposition date: 2018-04-24, release date: 2018-08-08, Last modification date: 2023-11-22) |
Primary citation | Chen, S.F.,Huang, N.L.,Lin, J.H.,Wu, C.C.,Wang, Y.R.,Yu, Y.J.,Gilson, M.K.,Chan, N.L. Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9:3085-3085, 2018 Cited by PubMed: 30082834DOI: 10.1038/s41467-018-05406-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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