5ZRF
Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA topoisomerase 2-beta | polymer | 803 | 91928.4 | 2 | UniProt (Q02880) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) | Homo sapiens (Human) | DNA topoisomerase II,beta isozyme |
| 2 | C, E (C, E) | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3') | polymer | 8 | 2436.6 | 2 | synthetic construct | ||
| 3 | D, F (D, F) | DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3') | polymer | 12 | 4038.0 | 2 | synthetic construct | ||
| 4 | G, H, I, J, L... (A, B, D, F) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) PubChem (888) | |||
| 5 | K, M (D, F) | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | non-polymer | 588.6 | 2 | Chemie (EVP) PubChem (16394664) PubChem (16401497) PubChem (17571827) PubChem (24214025) PubChem (16757762) PubChem (23947062) PubChem (40469452) PubChem (44399307) PubChem (50989217) PubChem (50936917) PubChem (54395107) PubChem (56841827) PubChem (44291969) PubChem (59360017) PubChem (44343101) PubChem (44439411) PubChem (59910346) PubChem (59991120) PubChem (45356822) PubChem (68297502) PubChem (143627016) PubChem (143179527) PubChem (36462) PubChem (284997) PubChem (73896870) PubChem (487698) PubChem (89809018) PubChem (91528489) PubChem (92209273) PubChem (71109688) PubChem (92211248) PubChem (92481363) PubChem (5284558) PubChem (98044669) PubChem (98456097) PubChem (99940883) PubChem (100810256) PubChem (6419930) PubChem (6604389) PubChem (122535989) PubChem (6708815) PubChem (124747955) PubChem (9851398) PubChem (129010358) PubChem (129427216) PubChem (129426541) PubChem (129539581) PubChem (129427217) PubChem (129539582) PubChem (134694737) PubChem (11870443) PubChem (11870444) PubChem (137370657) PubChem (13269642) PubChem (142236013) PubChem (146156165) PubChem (57835439) PubChem (155239770) PubChem (58934286) PubChem (171042228) PubChem (172012121) PubChem (59516320) PubChem (59890041) PubChem (59935043) PubChem (59969579) PubChem (59981749) PubChem (59981750) PubChem (60046278) PubChem (68028947) PubChem (70840214) PubChem (70973405) PubChem (71774979) PubChem (73707413) PubChem (90657341) PubChem (90721503) PubChem (90928389) PubChem (92209272) PubChem (92209274) PubChem (92209275) PubChem (92215927) PubChem (92481364) PubChem (96545492) PubChem (98044670) PubChem (98047570) PubChem (98047571) PubChem (98047572) PubChem (98456096) PubChem (98456098) PubChem (99940884) PubChem (101060364) PubChem (101616479) PubChem (101872048) PubChem (117627571) PubChem (117987058) PubChem (3310) PubChem (439525) PubChem (124747952) PubChem (124747953) PubChem (124747954) PubChem (124762382) PubChem (6604625) PubChem (6610299) PubChem (71163169) PubChem (9851399) PubChem (9916469) PubChem (10077076) PubChem (11072012) PubChem (129406641) PubChem (129416190) PubChem (129426542) PubChem (129426543) PubChem (129539580) PubChem (129539583) PubChem (11758093) PubChem (11870245) PubChem (11870445) PubChem (13269634) PubChem (13269638) PubChem (135056244) PubChem (137704929) PubChem (144658263) PubChem (145365700) PubChem (153427708) PubChem (154700020) PubChem (156133909) PubChem (163016457) PubChem (163016458) PubChem (163016459) PubChem (163016460) PubChem (163016461) PubChem (164643737) PubChem (164935527) PubChem (167092395) PubChem (168251311) PubChem (169440327) PubChem (172372122) | |||
| 6 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 524 | Chemie (HOH) |
Sequence modifications
A, B: 445 - 1201 (UniProt: Q02880)
| PDB | External Database | Details |
|---|---|---|
| Met 419 | - | expression tag |
| Ala 420 | - | expression tag |
| Ser 421 | - | expression tag |
| Trp 422 | - | expression tag |
| Ser 423 | - | expression tag |
| His 424 | - | expression tag |
| Pro 425 | - | expression tag |
| Gln 426 | - | expression tag |
| Phe 427 | - | expression tag |
| Glu 428 | - | expression tag |
| Lys 429 | - | expression tag |
| Gly 430 | - | expression tag |
| Ala 431 | - | expression tag |
| Asp 432 | - | expression tag |
| Asp 433 | - | expression tag |
| Asp 434 | - | expression tag |
| Asp 435 | - | expression tag |
| Lys 436 | - | expression tag |
| Val 437 | - | expression tag |
| Pro 438 | - | expression tag |
| Asp 439 | - | expression tag |
| Pro 440 | - | expression tag |
| Thr 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Val 443 | - | expression tag |
| Asp 444 | - | expression tag |
| Gly 1202 | - | expression tag |
| Ala 1203 | - | expression tag |
| Pro 1204 | - | expression tag |
| Gly 1205 | - | expression tag |
| Phe 1206 | - | expression tag |
| Ser 1207 | - | expression tag |
| Ser 1208 | - | expression tag |
| Ile 1209 | - | expression tag |
| Ser 1210 | - | expression tag |
| Ala 1211 | - | expression tag |
| His 1212 | - | expression tag |
| His 1213 | - | expression tag |
| His 1214 | - | expression tag |
| His 1215 | - | expression tag |
| His 1216 | - | expression tag |
| His 1217 | - | expression tag |
| His 1218 | - | expression tag |
| His 1219 | - | expression tag |
| His 1220 | - | expression tag |
| His 1221 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 196805.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1322.9 | |
| All* | Total formula weight | 198128.9 |
