PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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7ZPL	Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook 分子名称: 5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ... 著者 Cusack, S, Kouba, T. 登録日 2022-04-27 公開日 2022-12-28 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
3E51	Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-pyrrolidin-1-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. 登録日 2008-08-12 公開日 2009-08-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents. Bioorg.Med.Chem.Lett., 18, 2008
8W8F	human co-transcriptional RNA capping enzyme RNGTT-CMTR1 分子名称: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ... 著者 Li, Y, Wang, Q, Xu, Y, Li, Z. 登録日 2023-09-02 公開日 2024-04-10 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
8W8E	human co-transcriptional RNA capping enzyme RNGTT 分子名称: DNA (36-MER), DNA (45-MER), DNA-directed RNA polymerase II subunit E, ... 著者 Li, Y, Wang, Q, Xu, Y, Li, Z. 登録日 2023-09-02 公開日 2024-04-10 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
6VL3	The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986436 分子名称: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Jayaraman, S, Rankovic, Z, White, S.W. 登録日 2020-01-22 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6VJH	The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with SJ000986192 分子名称: 2-[2-[(cyclohexylmethyl-$l^{3}-oxidanyl)carbonylamino]propan-2-yl]-~{N}-[2-(5-methoxy-4-oxidanyl-cyclohexa-1,3,5-trien-1-yl)ethyl]-5-oxidanyl-6-oxidanylidene-pyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2020-01-16 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6VIV	The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986192 分子名称: 2-[2-[(cyclohexylmethyl-$l^{3}-oxidanyl)carbonylamino]propan-2-yl]-~{N}-[2-(5-methoxy-4-oxidanyl-cyclohexa-1,3,5-trien-1-yl)ethyl]-5-oxidanyl-6-oxidanylidene-pyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2020-01-14 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
1JZC	THE SOLUTION STRUCTURE OF THE MUTANT 5'AUG3' TRILOOP IN THE RNA PROMOTER REGION OF THE BROME MOSAIC VIRUS GENOMIC (+)-RNA 分子名称: 5'-R(*GP*GP*UP*GP*CP*AP*UP*GP*GP*CP*AP*CP*C)-3' 著者 Kim, C.-H, Kao, C.C. 登録日 2001-09-14 公開日 2003-10-07 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 A mutant viral RNA promoter with an altered conformation retains efficient recognition by a viral RNA replicase through a solution-exposed adenine RNA, 7, 2001
6P5K	Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3) 分子名称: 18S rRNA, 28S rRNA, 5.8S rRNA, ... 著者 Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. 登録日 2019-05-30 公開日 2019-09-18 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
6QCV	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP 分子名称: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6QCW	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
5M3J	Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD 分子名称: DNA-directed RNA polymerase subunit, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Pflug, A, Cusack, S. 登録日 2016-10-14 公開日 2016-12-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural basis of an essential interaction between influenza polymerase and Pol II CTD. Nature, 541, 2017
5M3H	Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Pflug, A, Cusack, S. 登録日 2016-10-14 公開日 2016-12-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of an essential interaction between influenza polymerase and Pol II CTD. Nature, 541, 2017
6P5J	Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2) 分子名称: 18S rRNA, 28S rRNA, 5.8S rRNA, ... 著者 Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. 登録日 2019-05-30 公開日 2019-09-18 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
6P5I	Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1) 分子名称: 18S rRNA, 28S rRNA, 5.8S rRNA, ... 著者 Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. 登録日 2019-05-30 公開日 2019-09-18 最終更新日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
5CHS	N-terminal domain of the vesicular stomatitis virus L protein 分子名称: PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase L, SODIUM ION 著者 Green, T.J, Qiu, S, Luo, M. 登録日 2015-07-10 公開日 2015-07-22 最終更新日 2020-08-26 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure and Function of the N-Terminal Domain of the Vesicular Stomatitis Virus RNA Polymerase. J.Virol., 90, 2015
7Q5B	Cryo-EM structure of Ty3 retrotransposon targeting a TFIIIB-bound tRNA gene 分子名称: DNA (19-MER), DNA (31-MER), DNA (34-MER), ... 著者 Abascal-Palacios, G, Jochem, L, Pla-Prats, C, Beuron, F, Vannini, A. 登録日 2021-11-03 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.98 Å) 主引用文献 Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes. Nat Commun, 12, 2021
7QTL	Influenza A/H7N9 polymerase elongation complex 分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... 著者 Cusack, S, Kouba, T. 登録日 2022-01-14 公開日 2022-12-28 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.48 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7R1F	Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-02-02 公開日 2022-12-28 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.58 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7R0E	Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position 分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2022-02-01 公開日 2022-12-28 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.51 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
6P5N	Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1 分子名称: 18S rRNA, 28S rRNA, 5.8S rRNA, ... 著者 Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. 登録日 2019-05-30 公開日 2019-09-25 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
7TQL	CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Lapointe, C.P, Grosely, R, Sokabe, M, Alvarado, C, Wang, J, Montabana, E, Villa, N, Shin, B, Dever, T, Fraser, C, Fernandez, I.S, Puglisi, J.D. 登録日 2022-01-26 公開日 2022-04-27 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. Nature, 607, 2022
4XLS	Crystal structure of T. aquaticus transcription initiation complex with CarD containing upstream fork promoter. 分子名称: CarD-like transcriptional regulator, DNA (30-MER), DNA (5'-D(P*GP*CP*AP*CP*AP*AP*TP*TP*TP*AP*AP*CP*AP*CP*TP*TP*TP*TP*GP*TP*CP*AP*AP*G)-3'), ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.01 Å) 主引用文献 CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
4WTJ	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-AUCC, RNA PRIMER 5'-PGG, MN2+, AND ADP 分子名称: 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTM	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP 分子名称: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER CC, ... 著者 Edwards, T.E, Appleby, T.C, Fox III, D. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015

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