6VJH

The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with SJ000986192

Summary for 6VJH

• Entry DOI: 10.2210/pdb6vjh/pdb
• Related: 5vpt
• Descriptor: Polymerase acidic protein, 2-[2-[(cyclohexylmethyl-$l^{3}-oxidanyl)carbonylamino]propan-2-yl]-~{N}-[2-(5-methoxy-4-oxidanyl-cyclohexa-1,3,5-trien-1-yl)ethyl]-5-oxidanyl-6-oxidanylidene-pyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, ... (5 entities in total)
• Functional Keywords: nuclease, influenza, inhibitor resistance, viral protein
• Biological source: Influenza A virus (A/Luxembourg/43/2009(H1N1)); More
• Total number of polymer chains: 1
• Total formula weight: 24423.60

Authors

Cuypers, M.G.,Slavish, P.J.,Rankovic, Z.,White, S.W. (deposition date: 2020-01-16, release date: 2021-02-10, Last modification date: 2023-10-25)

• Primary citation: Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W.; Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.; Eur.J.Med.Chem., 247:115035-115035, 2023; PubMed: 36603507; DOI: 10.1016/j.ejmech.2022.115035

Experimental method

X-RAY DIFFRACTION (2.55 Å)