PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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5UEP	BRD4_BD2_A-581577 分子名称: Bromodomain-containing protein 4, ethyl 3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate 著者 Park, C.H. 登録日 2017-01-03 公開日 2017-06-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Complex structure of BRD4_BD2_A-581577 To Be Published
5UET	BRD4_BD2_A-1308586 分子名称: 2-methyl-5-phenyl-1H-pyrrole-3-carboxamide, Bromodomain-containing protein 4 著者 Park, C.H. 登録日 2017-01-03 公開日 2017-06-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Complex structure of BRD4_BD2_A-1308586 To Be Published
1D3G	HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG 分子名称: 2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... 著者 Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J. 登録日 1999-09-29 公開日 2000-09-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure Fold.Des., 8, 2000
5UEY	BRD4_BD2_A-1412838 分子名称: 5-[2-(2,4-difluorophenoxy)-5-{[ethyl(dihydroxy)-lambda~4~-sulfanyl]amino}phenyl]-4-ethoxy-1-methylpyridin-2(1H)-one, Bromodomain-containing protein 4 著者 Park, C.H. 登録日 2017-01-03 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors. J. Med. Chem., 60, 2017
5J0Y	Binary complex crystal structure of DNA polymerase Beta with T:T mismatch at the primer terminus 分子名称: DNA polymerase beta, Downstream Primer Strand, Primer Strand, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2016-03-28 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure, 24, 2016
1TEV	Crystal structure of the human UMP/CMP kinase in open conformation 分子名称: SULFATE ION, UMP-CMP kinase 著者 Segura-Pena, D, Sekulic, N, Ort, S, Konrad, M, Lavie, A. 登録日 2004-05-25 公開日 2004-06-22 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Substrate-induced Conformational Changes in Human UMP/CMP Kinase. J.Biol.Chem., 279, 2004
5IZU	A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function 分子名称: SH3 and multiple ankyrin repeat domains protein 3, peptide from Disks large-associated protein 3 著者 Shang, Y, Zeng, M, Zhang, M. 登録日 2016-03-26 公開日 2016-05-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.494 Å) 主引用文献 A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function Proc.Natl.Acad.Sci.USA, 113, 2016
5J29	Ternary complex crystal structure of DNA polymerase Beta with A:A mismatch at the primer terminus 分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA polymerase beta, Downstream Primer Strand, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2016-03-29 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure, 24, 2016
5J2G	Ternary complex crystal structure of DNA polymerase Beta with G:G mismatch at the primer terminus 分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA polymerase beta, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2016-03-29 公開日 2016-10-26 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure, 24, 2016
5J0P	Binary complex crystal structure of DNA polymerase Beta with A:C mismatch at the primer terminus 分子名称: DNA polymerase beta, Downstream Primer Strand, Primer Strand, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2016-03-28 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure, 24, 2016
5UC9	Crystal structure of human Heme Oxygenase-2 in complex with Myristate 分子名称: Heme oxygenase 2, MYRISTIC ACID 著者 Luo, S, Tong, L. 登録日 2016-12-22 公開日 2017-02-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.903 Å) 主引用文献 Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling. Cell Host Microbe, 21, 2017
5J0S	Binary complex crystal structure of DNA polymerase Beta with C:T mismatch at the primer terminus 分子名称: DNA polymerase beta, Downstream Primer Strand, Primer Strand, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2016-03-28 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure, 24, 2016
4WU8	Structure of trPtNAP-NCP145 分子名称: DNA (145-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Chua, E.Y.D, Davey, C.A. 登録日 2014-10-31 公開日 2015-09-02 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents. Nucleic Acids Res., 43, 2015
5J39	Crystal Structure of the extended TUDOR domain from TDRD2 分子名称: CACODYLATE ION, Tudor and KH domain-containing protein, UNKNOWN ATOM OR ION 著者 Zhang, H, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2016-03-30 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1D7X	CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A MODIFIED PROLINE SCAFFOLD BASED INHIBITOR. 分子名称: CALCIUM ION, N-HYDROXY 1N(4-METHOXYPHENYL)SULFONYL-4-(Z,E-N-METHOXYIMINO)PYRROLIDINE-2R-CARBOXAMIDE, STROMELYSIN-1 PRECURSOR, ... 著者 Cheng, M.Y, Natchus, M.G, De, B, Almstead, N.G, Pikul, S. 登録日 1999-10-20 公開日 2000-10-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. J.Med.Chem., 42, 1999
5IVY	Linked KDM5A Jmj Domain Bound to the Inhibitor N16 [3-(2-(4-chlorophenyl)acetamido)isonicotinic acid] 分子名称: 3-{[(4-chlorophenyl)acetyl]amino}pyridine-4-carboxylic acid, Lysine-specific demethylase 5A, MANGANESE (II) ION 著者 Horton, J.R, Cheng, X. 登録日 2016-03-21 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
5J2E	Ternary complex crystal structure of DNA polymerase Beta with C:T mismatch at the primer terminus 分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA polymerase beta, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2016-03-29 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure, 24, 2016
1UHL	Crystal structure of the LXRalfa-RXRbeta LBD heterodimer 分子名称: (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID, 10-mer peptide from Nuclear receptor coactivator 2, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, ... 著者 Svensson, S, Ostberg, T, Jacobsson, M, Norstrom, C, Stefansson, K, Hallen, D, Johansson, I.C, Zachrisson, K, Ogg, D, Jendeberg, L. 登録日 2003-07-03 公開日 2004-06-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation Embo J., 22, 2003
3K7J	Crystal structure of the D100E mutant of the Indian Hedgehog N-terminal signalling domain 分子名称: CARBONATE ION, Indian hedgehog protein, SULFATE ION, ... 著者 He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. 登録日 2009-10-13 公開日 2011-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the D100E mutant of the Indian Hedgehog N-terminal signalling domain To be Published
1UHP	Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095 分子名称: hypothetical protein KIAA1095 著者 Hamada, T, Muto, Y, Hirota, H, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-07-09 公開日 2004-01-09 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095 To be published
1CKL	N-TERMINAL TWO DOMAINS OF HUMAN CD46 (MEMBRANE COFACTOR PROTEIN, MCP) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Casasnovas, J, Larvie, M, Stehle, T. 登録日 1999-04-22 公開日 1999-06-11 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of two CD46 domains reveals an extended measles virus-binding surface. EMBO J., 18, 1999
5J0U	Binary complex crystal structure of DNA polymerase Beta with G:G mismatch at the primer terminus 分子名称: DNA polymerase beta, Downstream Primer Strand, Primer Strand, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2016-03-28 公開日 2016-10-26 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure, 24, 2016
1D4A	CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AT 1.7 A RESOLUTION 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, QUINONE REDUCTASE 著者 Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M. 登録日 1999-10-01 公開日 1999-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release. Proc.Natl.Acad.Sci.USA, 97, 2000
5J13	Structural basis for TSLP antagonism by the therapeutic antibody Tezepelumab (MEDI9929 / AMG-157) 分子名称: SULFATE ION, Thymic stromal lymphopoietin, anti-TSLP Fab-fragment, ... 著者 Verstraete, K, Savvides, S.N. 登録日 2016-03-28 公開日 2017-04-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.298 Å) 主引用文献 Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. Nat Commun, 8, 2017
5U52	2 helix minimized version of the B-domain from Protein A (Z34C0 bound to IgG1 Fc (monoclinic form) 分子名称: IGG1 FC, Mini Z domain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Ultsch, M.H, Eigenbrot, C. 登録日 2016-12-06 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.942 Å) 主引用文献 3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix. Protein Eng. Des. Sel., 30, 2017

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