5IVY
Linked KDM5A Jmj Domain Bound to the Inhibitor N16 [3-(2-(4-chlorophenyl)acetamido)isonicotinic acid]
Summary for 5IVY
| Entry DOI | 10.2210/pdb5ivy/pdb |
| Related | 5ISB 5ISL 5IVC 5IVE 5IVF 5IVJ 5IVV 5IW0 5IWF |
| Descriptor | Lysine-specific demethylase 5A, 3-{[(4-chlorophenyl)acetyl]amino}pyridine-4-carboxylic acid, MANGANESE (II) ION, ... (4 entities in total) |
| Functional Keywords | demethylase inhibition, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus, nucleolus : P29375 |
| Total number of polymer chains | 1 |
| Total formula weight | 38290.48 |
| Authors | Horton, J.R.,Cheng, X. (deposition date: 2016-03-21, release date: 2016-07-27, Last modification date: 2023-09-27) |
| Primary citation | Horton, J.R.,Liu, X.,Gale, M.,Wu, L.,Shanks, J.R.,Zhang, X.,Webber, P.J.,Bell, J.S.,Kales, S.C.,Mott, B.T.,Rai, G.,Jansen, D.J.,Henderson, M.J.,Urban, D.J.,Hall, M.D.,Simeonov, A.,Maloney, D.J.,Johns, M.A.,Fu, H.,Jadhav, A.,Vertino, P.M.,Yan, Q.,Cheng, X. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23:769-781, 2016 Cited by PubMed: 27427228DOI: 10.1016/j.chembiol.2016.06.006 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
Download full validation report
