5IVJ

Linked KDM5A Jmj Domain Bound to the Inhibitor N11 [3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid]

Summary for 5IVJ

Entry DOI	10.2210/pdb5ivj/pdb
Related	5ISL 5IVB 5IVC 5IVE 5IVF 5IVV 5IVY 5IW0 5IWF
Descriptor	Lysine-specific demethylase 5A, 3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid, MANGANESE (II) ION, ... (6 entities in total)
Functional Keywords	demethylase inhibition, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus, nucleolus : P29375
Total number of polymer chains	1
Total formula weight	38589.40
Authors	Horton, J.R.,Cheng, X. (deposition date: 2016-03-21, release date: 2016-07-27, Last modification date: 2023-09-27)
Primary citation	Horton, J.R.,Liu, X.,Gale, M.,Wu, L.,Shanks, J.R.,Zhang, X.,Webber, P.J.,Bell, J.S.,Kales, S.C.,Mott, B.T.,Rai, G.,Jansen, D.J.,Henderson, M.J.,Urban, D.J.,Hall, M.D.,Simeonov, A.,Maloney, D.J.,Johns, M.A.,Fu, H.,Jadhav, A.,Vertino, P.M.,Yan, Q.,Cheng, X. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23:769-781, 2016 Cited by PubMed: 27427228 DOI: 10.1016/j.chembiol.2016.06.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.569 Å)

Structure validation