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1D7X

CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A MODIFIED PROLINE SCAFFOLD BASED INHIBITOR.

Summary for 1D7X
Entry DOI10.2210/pdb1d7x/pdb
Related1CQR 1D5J
DescriptorSTROMELYSIN-1 PRECURSOR, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmixed alpha beta structure, zinc protease, inhibited, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (Probable): P08254
Total number of polymer chains2
Total formula weight40025.90
Authors
Cheng, M.Y.,Natchus, M.G.,De, B.,Almstead, N.G.,Pikul, S. (deposition date: 1999-10-20, release date: 2000-10-23, Last modification date: 2024-02-07)
Primary citationCheng, M.,De, B.,Almstead, N.G.,Pikul, S.,Dowty, M.E.,Dietsch, C.R.,Dunaway, C.M.,Gu, F.,Hsieh, L.C.,Janusz, M.J.,Taiwo, Y.O.,Natchus, M.G.,Hudlicky, T.,Mandel, M.
Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold.
J.Med.Chem., 42:5426-5436, 1999
Cited by
PubMed: 10639284
DOI: 10.1021/jm9904699
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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