1D5J

CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR.

Summary for 1D5J

Entry DOI	10.2210/pdb1d5j/pdb
Related	1CQR
Descriptor	STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	mixed alpha beta structure, zinc protease, inhibited, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	40084.11
Authors	Almstead, N.G.,Bradley, R.S.,Pikul, S.,De, B.,Natchus, M.G. (deposition date: 1999-10-07, release date: 2000-10-09, Last modification date: 2024-02-07)
Primary citation	Almstead, N.G.,Bradley, R.S.,Pikul, S.,De, B.,Natchus, M.G.,Taiwo, Y.O.,Gu, F.,Williams, L.E.,Hynd, B.A.,Janusz, M.J.,Dunaway, C.M.,Mieling, G.E. Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. J.Med.Chem., 42:4547-4562, 1999 Cited by PubMed: 10579818 DOI: 10.1021/jm990330y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation