1D5J
CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR.
Summary for 1D5J
Entry DOI | 10.2210/pdb1d5j/pdb |
Related | 1CQR |
Descriptor | STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mixed alpha beta structure, zinc protease, inhibited, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 40084.11 |
Authors | Almstead, N.G.,Bradley, R.S.,Pikul, S.,De, B.,Natchus, M.G. (deposition date: 1999-10-07, release date: 2000-10-09, Last modification date: 2024-02-07) |
Primary citation | Almstead, N.G.,Bradley, R.S.,Pikul, S.,De, B.,Natchus, M.G.,Taiwo, Y.O.,Gu, F.,Williams, L.E.,Hynd, B.A.,Janusz, M.J.,Dunaway, C.M.,Mieling, G.E. Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. J.Med.Chem., 42:4547-4562, 1999 Cited by PubMed: 10579818DOI: 10.1021/jm990330y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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