4GBW
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![BU of 4gbw by Molmil](/molmil-images/mine/4gbw) | Crystal Structure of AMP complexes of Porcine Liver Fructose-1,6-bisphosphatase Mutant A54L with 1,2-propanediol as Cryo-protectant | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | 著者 | Honzatko, R.B, Gao, Y. | 登録日 | 2012-07-28 | 公開日 | 2013-08-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Water Structure of the Central Hydrophobic Cavity of Mammalian Fructose-1,6-bisphosphatase: a Potential Thermodynamic Determinant of Allowed Quaternary States To be published
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6ET9
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![BU of 6et9 by Molmil](/molmil-images/mine/6et9) | Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetyl-CoA acetyltransferase thiolase, CHLORIDE ION, ... | 著者 | Engilberge, S, Voegeli, B, Girard, E, Riobe, F, Maury, O, Erb, T.J, Shima, S, Wagner, T. | 登録日 | 2017-10-25 | 公開日 | 2018-03-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1PED
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![BU of 1ped by Molmil](/molmil-images/mine/1ped) | BACTERIAL SECONDARY ALCOHOL DEHYDROGENASE (APO-FORM) | 分子名称: | NADP-DEPENDENT ALCOHOL DEHYDROGENASE, ZINC ION | 著者 | Korkhin, Y, Frolow, F. | 登録日 | 1995-12-28 | 公開日 | 1997-07-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystalline alcohol dehydrogenases from the mesophilic bacterium Clostridium beijerinckii and the thermophilic bacterium Thermoanaerobium brockii: preparation, characterization and molecular symmetry. Acta Crystallogr.,Sect.D, 52, 1996
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4XUN
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4H4A
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4HN4
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![BU of 4hn4 by Molmil](/molmil-images/mine/4hn4) | Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor in the alpha site | 分子名称: | 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, BICINE, ... | 著者 | Hilario, E, Niks, D, Dunn, M.F, Mueller, L.J, Fan, L. | 登録日 | 2012-10-18 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52, 2013
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1V4G
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![BU of 1v4g by Molmil](/molmil-images/mine/1v4g) | Crystal Structure of gamma-Glutamylcysteine Synthetase from Escherichia coli B | 分子名称: | Glutamate--cysteine ligase | 著者 | Hibi, T, Nii, H, Nakatsu, T, Kato, H, Hiratake, J, Oda, J. | 登録日 | 2003-11-13 | 公開日 | 2004-10-05 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis PROC.NATL.ACAD.SCI.USA, 101, 2004
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5AYY
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![BU of 5ayy by Molmil](/molmil-images/mine/5ayy) | CRYSTAL STRUCTURE OF HUMAN QUINOLINATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH THE REACTANT QUINOLINATE | 分子名称: | Nicotinate-nucleotide pyrophosphorylase [carboxylating], QUINOLINIC ACID | 著者 | Youn, H.S, Kim, T.G, Kim, M.K, Kang, G.B, Kang, J.Y, Seo, Y.J, Lee, J.G, An, J.Y, Park, K.R, Lee, Y, Im, Y.J, Lee, J.H, Fukuoka, S.I, Eom, S.H. | 登録日 | 2015-09-14 | 公開日 | 2016-02-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis Sci Rep, 6, 2016
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4HKG
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![BU of 4hkg by Molmil](/molmil-images/mine/4hkg) | Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Allen, C.L, Gulick, A.M. | 登録日 | 2012-10-15 | 公開日 | 2013-10-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.3002 Å) | 主引用文献 | Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein. Acta Crystallogr. D Biol. Crystallogr., 70, 2014
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1HI0
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![BU of 1hi0 by Molmil](/molmil-images/mine/1hi0) | RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus initiation complex | 分子名称: | DNA (5'-(*TP*TP*TP*CP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | 登録日 | 2000-12-31 | 公開日 | 2001-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
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3NAY
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![BU of 3nay by Molmil](/molmil-images/mine/3nay) | PDK1 in complex with inhibitor MP6 | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 4-(2-cyclopropylethylidene)-9-(1H-pyrazol-4-yl)-6-{[(1R)-1,2,2-trimethylpropyl]amino}benzo[c][1,6]naphthyridin-1(4H)-one | 著者 | Yan, Y, Munshi, S.K, Allison, T. | 登録日 | 2010-06-02 | 公開日 | 2010-11-24 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines J.Biol.Chem., 2010
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3NCY
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![BU of 3ncy by Molmil](/molmil-images/mine/3ncy) | X-ray crystal structure of an arginine agmatine antiporter (AdiC) in complex with a Fab fragment | 分子名称: | AdiC, Fab Heavy chain, Fab Light chain | 著者 | Fang, Y, Jayaram, H, Shane, T, Komalkova-Partensky, L, Wu, F, Williams, C, Xiong, Y, Miller, C. | 登録日 | 2010-06-06 | 公開日 | 2010-08-18 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Nature, 460, 2009
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5AZA
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3NQ1
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![BU of 3nq1 by Molmil](/molmil-images/mine/3nq1) | Crystal Structure of Tyrosinase from Bacillus megaterium in complex with inhibitor kojic acid | 分子名称: | 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE, COPPER (II) ION, Tyrosinase, ... | 著者 | Sendovski, M, Kanteev, M, Adir, N, Fishman, A. | 登録日 | 2010-06-29 | 公開日 | 2010-11-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | First structures of an active bacterial tyrosinase reveal copper plasticity. J.Mol.Biol., 405, 2011
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3NQ5
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![BU of 3nq5 by Molmil](/molmil-images/mine/3nq5) | Crystal Structure of Tyrosinase from Bacillus megaterium R209H mutant | 分子名称: | COPPER (II) ION, Tyrosinase, ZINC ION | 著者 | Sendovski, M, Kanteev, M, Adir, N, Fishman, A. | 登録日 | 2010-06-29 | 公開日 | 2010-11-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | First structures of an active bacterial tyrosinase reveal copper plasticity. J.Mol.Biol., 405, 2011
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3NZM
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4ERZ
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![BU of 4erz by Molmil](/molmil-images/mine/4erz) | X-ray structure of WDR5-MLL4 Win motif peptide binary complex | 分子名称: | Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5 | 著者 | Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. | 登録日 | 2012-04-21 | 公開日 | 2012-05-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287, 2012
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4EVU
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![BU of 4evu by Molmil](/molmil-images/mine/4evu) | Crystal structure of C-terminal domain of putative periplasmic protein ydgH from S. enterica | 分子名称: | CHLORIDE ION, Putative periplasmic protein ydgH, SULFATE ION | 著者 | Michalska, K, Cui, H, Xu, X, Brown, R.N, Cort, J.R, Heffron, F, Nakayasu, E.S, Savchenko, A, Adkins, J.N, Joachimiak, A, Program for the Characterization of Secreted Effector Proteins (PCSEP), Midwest Center for Structural Genomics (MCSG) | 登録日 | 2012-04-26 | 公開日 | 2012-05-30 | 最終更新日 | 2014-07-30 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO. Plos One, 9, 2014
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4HT3
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![BU of 4ht3 by Molmil](/molmil-images/mine/4ht3) | The crystal structure of Salmonella typhimurium Tryptophan Synthase at 1.30A complexed with N-(4'-TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1-ETHYLPHOSPHATE (F9) inhibitor in the alpha site, internal aldimine | 分子名称: | 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... | 著者 | Hilario, E, Niks, D, Dunn, M.F, Mueller, L.J, Fan, L. | 登録日 | 2012-10-31 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52, 2013
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1OKJ
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4HPX
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![BU of 4hpx by Molmil](/molmil-images/mine/4hpx) | Crystal structure of Tryptophan Synthase at 1.65 A resolution in complex with alpha aminoacrylate E(A-A) and benzimidazole in the beta site and the F9 inhibitor in the alpha site | 分子名称: | 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, BENZIMIDAZOLE, ... | 著者 | Hilario, E, Niks, D, Dunn, M.F, Mueller, L.J, Fan, L. | 登録日 | 2012-10-24 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52, 2013
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4HTY
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4HPJ
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![BU of 4hpj by Molmil](/molmil-images/mine/4hpj) | Crystal structure of Tryptophan Synthase at 1.45 A resolution in complex with 2-aminophenol quinonoid in the beta site and the F9 inhibitor in the alpha site | 分子名称: | (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]-3-[(2-hydroxyphenyl)amino]propanoic acid, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, BICINE, ... | 著者 | Hilario, E, Niks, D, Dunn, M.F, Mueller, L.J, Fan, L. | 登録日 | 2012-10-23 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52, 2013
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1VA6
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![BU of 1va6 by Molmil](/molmil-images/mine/1va6) | Crystal structure of Gamma-glutamylcysteine synthetase from Escherichia Coli B complexed with Transition-state analogue | 分子名称: | (2S)-2-AMINO-4-[[(2R)-2-CARBOXYBUTYL](PHOSPHONO)SULFONIMIDOYL]BUTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, Glutamate--cysteine ligase, ... | 著者 | Hibi, T, Nii, H, Nakatsu, T, Kato, H, Hiratake, J, Oda, J. | 登録日 | 2004-02-12 | 公開日 | 2004-10-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis PROC.NATL.ACAD.SCI.USA, 101, 2004
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1PY5
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![BU of 1py5 by Molmil](/molmil-images/mine/1py5) | Crystal Structure of TGF-beta receptor I kinase with inhibitor | 分子名称: | 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE, SULFATE ION, TGF-beta receptor type I | 著者 | Zhang, F, Sawyer, J.S. | 登録日 | 2003-07-08 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. Bioorg.Med.Chem.Lett., 14, 2004
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