3NAY

PDK1 in complex with inhibitor MP6

Summary for 3NAY

• Entry DOI: 10.2210/pdb3nay/pdb
• Related: 3NAX
• Descriptor: 3-phosphoinositide-dependent protein kinase 1, 4-(2-cyclopropylethylidene)-9-(1H-pyrazol-4-yl)-6-{[(1R)-1,2,2-trimethylpropyl]amino}benzo[c][1,6]naphthyridin-1(4H)-one (3 entities in total)
• Functional Keywords: kinase, serine/threonine protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O15530
• Total number of polymer chains: 2
• Total formula weight: 73203.96

Authors

Yan, Y.,Munshi, S.K.,Allison, T. (deposition date: 2010-06-02, release date: 2010-11-24, Last modification date: 2018-01-24)

• Primary citation: Nagashima, K.,Shumway, S.D.,Sathyanarayanan, S.,Chen, A.,Dolinski, B.,Xu, Y.,Keilhack, H.,Nguyen, T.,Wiznerowicz, M.,Li, L.,Lutterbach, B.A.,Paweletz, C.,Allison, T.,Yan, Y.,Munshi, S.K.,Klippel, A.,Kraus, M.,Bobkova, E.V.,Deshmukh, S.,Xu, Z.,Mueller, U.,Szewczak, A.A.,Pan, B.-S.,Richon, V.,Pollock, R.,Blume-Jensen, P.,Northrup, A.,Andersen, J.N.; Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines; J.Biol.Chem., 2010

Experimental method

X-RAY DIFFRACTION (2.6 Å)