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3NAY

PDK1 in complex with inhibitor MP6

Summary for 3NAY
Entry DOI10.2210/pdb3nay/pdb
Related3NAX
Descriptor3-phosphoinositide-dependent protein kinase 1, 4-(2-cyclopropylethylidene)-9-(1H-pyrazol-4-yl)-6-{[(1R)-1,2,2-trimethylpropyl]amino}benzo[c][1,6]naphthyridin-1(4H)-one (3 entities in total)
Functional Keywordskinase, serine/threonine protein kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: O15530
Total number of polymer chains2
Total formula weight73203.96
Authors
Yan, Y.,Munshi, S.K.,Allison, T. (deposition date: 2010-06-02, release date: 2010-11-24, Last modification date: 2024-11-06)
Primary citationNagashima, K.,Shumway, S.D.,Sathyanarayanan, S.,Chen, A.,Dolinski, B.,Xu, Y.,Keilhack, H.,Nguyen, T.,Wiznerowicz, M.,Li, L.,Lutterbach, B.A.,Paweletz, C.,Allison, T.,Yan, Y.,Munshi, S.K.,Klippel, A.,Kraus, M.,Bobkova, E.V.,Deshmukh, S.,Xu, Z.,Mueller, U.,Szewczak, A.A.,Pan, B.-S.,Richon, V.,Pollock, R.,Blume-Jensen, P.,Northrup, A.,Andersen, J.N.
Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines
J.Biol.Chem., 2010
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

227561

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