6ET9

Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A

Summary for 6ET9

Entry DOI	10.2210/pdb6et9/pdb
Descriptor	Acetyl-CoA acetyltransferase thiolase, ZINC ION, Pfam DUF35, ... (11 entities in total)
Functional Keywords	isoprenoid synthesis, enzymatic channeling, mevalonate production, archaea, lipid biosynthesis, multi-enzymatic complex, scaffold protein, duf35 family, transferase
Biological source	Methanothermococcus thermolithotrophicus More
Total number of polymer chains	12
Total formula weight	380273.98
Authors	Engilberge, S.,Voegeli, B.,Girard, E.,Riobe, F.,Maury, O.,Erb, T.J.,Shima, S.,Wagner, T. (deposition date: 2017-10-25, release date: 2018-03-14, Last modification date: 2018-04-11)
Primary citation	Vogeli, B.,Engilberge, S.,Girard, E.,Riobe, F.,Maury, O.,Erb, T.J.,Shima, S.,Wagner, T. Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115:3380-3385, 2018 Cited by PubMed: 29531083 DOI: 10.1073/pnas.1718649115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation