6ET9
Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0016746 | molecular_function | acyltransferase activity |
| J | 0016746 | molecular_function | acyltransferase activity |
| K | 0016746 | molecular_function | acyltransferase activity |
| L | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 401 |
| Chain | Residue |
| A | LYS314 |
| A | ILE315 |
| A | ARG316 |
| A | TYR319 |
| A | PHE322 |
| A | VAL323 |
| A | THR324 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue TRS A 402 |
| Chain | Residue |
| D | HOH516 |
| A | THR365 |
| D | LYS302 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue TRS A 404 |
| Chain | Residue |
| A | HOH511 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue K A 405 |
| Chain | Residue |
| A | THR255 |
| A | GLU296 |
| A | ASP297 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue TRS B 402 |
| Chain | Residue |
| B | LYS266 |
| B | HOH527 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue K B 403 |
| Chain | Residue |
| B | ASP36 |
| B | LYS354 |
| D | GLU232 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue TRS C 401 |
| Chain | Residue |
| A | LYS266 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue K C 402 |
| Chain | Residue |
| C | ASP36 |
| C | GLU232 |
| C | LYS354 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 403 |
| Chain | Residue |
| C | GLY41 |
| F | ARG39 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue MG D 401 |
| Chain | Residue |
| B | ASP40 |
| D | ASN38 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue NA D 402 |
| Chain | Residue |
| D | GLY335 |
| D | THR341 |
| D | ARG344 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue TRS D 403 |
| Chain | Residue |
| D | LYS266 |
| D | HOH521 |
| D | HOH527 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue K D 404 |
| Chain | Residue |
| D | ASP36 |
| D | GLU232 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 201 |
| Chain | Residue |
| E | CYS20 |
| E | CYS23 |
| E | CYS34 |
| E | CYS37 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue CL E 203 |
| Chain | Residue |
| B | GLY41 |
| E | ARG38 |
| E | HOH318 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 201 |
| Chain | Residue |
| F | CYS20 |
| F | CYS23 |
| F | CYS34 |
| F | CYS37 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue TRS F 202 |
| Chain | Residue |
| F | LYS10 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 201 |
| Chain | Residue |
| G | CYS20 |
| G | CYS23 |
| G | CYS34 |
| G | CYS37 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue TRS G 202 |
| Chain | Residue |
| G | TRP6 |
| G | LYS10 |
| K | LYS212 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue CL G 203 |
| Chain | Residue |
| D | GLY41 |
| G | ARG38 |
| G | ARG39 |
| G | HOH328 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 201 |
| Chain | Residue |
| H | CYS20 |
| H | CYS23 |
| H | CYS34 |
| H | CYS37 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue TRS H 202 |
| Chain | Residue |
| H | LYS10 |
| H | HOH301 |
| J | LYS212 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue CL H 203 |
| Chain | Residue |
| H | ARG38 |
| H | ARG39 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue K I 401 |
| Chain | Residue |
| I | GLU111 |
| K | GLU111 |
| site_id | AE7 |
| Number of Residues | 1 |
| Details | binding site for residue K I 402 |
| Chain | Residue |
| I | ASP3 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue CL I 403 |
| Chain | Residue |
| I | LYS89 |
| I | HOH521 |
| K | PHE112 |
| K | ALA113 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue GOL I 405 |
| Chain | Residue |
| I | GLU32 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue NA J 401 |
| Chain | Residue |
| J | PRO148 |
| J | GLY149 |
| J | ASP150 |
| J | GLU153 |
| J | TYR154 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue K J 402 |
| Chain | Residue |
| J | GLU111 |
| L | GLU111 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue K K 401 |
| Chain | Residue |
| K | GLU72 |
| K | ALA101 |
| K | ASP104 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue GOL K 402 |
| Chain | Residue |
| K | ASN177 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL L 401 |
| Chain | Residue |
| L | LYS19 |
| L | TYR334 |
