4HT3

The crystal structure of Salmonella typhimurium Tryptophan Synthase at 1.30A complexed with N-(4'-TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1-ETHYLPHOSPHATE (F9) inhibitor in the alpha site, internal aldimine

Summary for 4HT3

Entry DOI	10.2210/pdb4ht3/pdb
Related	2CLE 2CLF 2CLI 2RH9 2RHG 4HN4 4HPJ 4HPX
Descriptor	Tryptophan synthase alpha chain, PYRIDOXAL-5'-PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... (12 entities in total)
Functional Keywords	lyase, carbon-oxygen lyase, tryptophan biosynthesis, salmonella, f9f, allosteric enzyme, amino-acid biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, cesium ion, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium More
Total number of polymer chains	2
Total formula weight	74991.28
Authors	Hilario, E.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2012-10-31, release date: 2014-01-01, Last modification date: 2023-09-20)
Primary citation	Niks, D.,Hilario, E.,Dierkers, A.,Ngo, H.,Borchardt, D.,Neubauer, T.J.,Fan, L.,Mueller, L.J.,Dunn, M.F. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52:6396-6411, 2013 Cited by PubMed: 23952479 DOI: 10.1021/bi400795e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation