Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006568 | biological_process | tryptophan metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | tryptophan metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE F9F A 301 |
| Chain | Residue |
| A | PHE22 |
| A | THR183 |
| A | GLY184 |
| A | PHE212 |
| A | GLY213 |
| A | ILE232 |
| A | GLY234 |
| A | SER235 |
| A | HOH406 |
| A | HOH411 |
| A | HOH415 |
| A | GLU49 |
| B | PRO18 |
| A | ALA59 |
| A | ILE64 |
| A | LEU100 |
| A | LEU127 |
| A | ALA129 |
| A | ILE153 |
| A | TYR175 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BCN A 302 |
| Chain | Residue |
| A | SER247 |
| A | PRO248 |
| A | LYS249 |
| A | GLN250 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 304 |
| Chain | Residue |
| A | SER221 |
| A | ALA265 |
| A | ARG267 |
| B | LYS99 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PGE A 305 |
| Chain | Residue |
| A | PHE107 |
| A | ILE111 |
| A | GLU135 |
| A | PRO138 |
| A | PHE139 |
| A | HOH416 |
| A | HOH435 |
| A | HOH601 |
| A | HOH674 |
| B | TYR16 |
| B | LYS283 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PG5 A 306 |
| Chain | Residue |
| A | ARG164 |
| A | VAL166 |
| A | ALA167 |
| A | SER168 |
| A | GLY170 |
| A | ARG171 |
| A | THR174 |
| A | TYR203 |
| A | HIS204 |
| A | ALA205 |
| A | ALA206 |
| A | HOH663 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 307 |
| Chain | Residue |
| A | PRO93 |
| A | ALA137 |
| A | ARG140 |
| A | GLN141 |
| A | EDO308 |
| A | HOH455 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 308 |
| Chain | Residue |
| A | PRO93 |
| A | THR94 |
| A | EDO307 |
| A | HOH430 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 309 |
| Chain | Residue |
| A | ALA86 |
| A | LEU87 |
| A | GLU90 |
| A | ARG171 |
| A | HOH482 |
| A | HOH487 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP B 401 |
| Chain | Residue |
| B | HIS86 |
| B | LYS87 |
| B | GLN114 |
| B | THR190 |
| B | CYS230 |
| B | GLY232 |
| B | GLY233 |
| B | GLY234 |
| B | SER235 |
| B | ASN236 |
| B | GLY303 |
| B | GLU350 |
| B | SER377 |
| B | GLY378 |
| B | HOH502 |
| B | HOH684 |
| B | HOH937 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 402 |
| Chain | Residue |
| B | LYS87 |
| B | THR110 |
| B | GLY111 |
| B | ALA112 |
| B | GLY113 |
| B | GLN114 |
| B | HIS115 |
| B | EDO419 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE B 403 |
| Chain | Residue |
| B | HOH893 |
| B | LEU271 |
| B | LYS272 |
| B | GLY274 |
| B | PRO285 |
| B | ASN317 |
| B | GLU364 |
| B | CL423 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 404 |
| site_id | BC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE BCN B 405 |
| Chain | Residue |
| B | GLY259 |
| B | HIS260 |
| B | GLU263 |
| B | THR328 |
| B | ASP329 |
| B | ASP330 |
| B | EDO413 |
| B | EDO414 |
| B | HOH539 |
| B | HOH771 |
| B | HOH773 |
| B | HOH897 |
| B | HOH904 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE BCN B 406 |
| Chain | Residue |
| B | THR248 |
| B | VAL250 |
| B | GLY251 |
| B | LEU252 |
| B | GLY320 |
| B | ARG321 |
| B | ASP323 |
| B | HOH780 |
| B | HOH803 |
| B | HOH856 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCN B 407 |
| Chain | Residue |
| B | THR289 |
| B | ALA290 |
| B | ASP291 |
| B | GLN293 |
| B | HOH581 |
| B | HOH599 |
| B | HOH764 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 408 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 409 |
| Chain | Residue |
| B | ASP47 |
| B | LYS61 |
| B | LYS219 |
| B | PEG416 |
| B | HOH522 |
| B | HOH553 |
| B | HOH795 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 410 |
| Chain | Residue |
| B | HIS273 |
| B | VAL325 |
| B | SER326 |
| B | HOH578 |
| B | HOH664 |
| B | HOH716 |
| B | HOH794 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS B 411 |
| Chain | Residue |
| B | THR66 |
| B | THR69 |
| B | THR71 |
| B | HOH822 |
| B | HOH948 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CS B 412 |
| Chain | Residue |
| B | VAL231 |
| B | GLY232 |
| B | GLU256 |
| B | GLY268 |
| B | PRO270 |
| B | LEU304 |
| B | PHE306 |
| B | SER308 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 413 |
| Chain | Residue |
| B | ASP330 |
| B | GLU331 |
| B | BCN405 |
| B | EDO414 |
| B | HOH586 |
| B | HOH693 |
| B | HOH771 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 414 |
| Chain | Residue |
| B | THR328 |
| B | BCN405 |
| B | EDO413 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 415 |
| Chain | Residue |
| B | THR3 |
| B | LEU4 |
| B | ASN6 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG B 416 |
| Chain | Residue |
| B | ASN51 |
| B | TYR52 |
| B | THR60 |
| B | LYS61 |
| B | LEU125 |
| B | GLU343 |
| B | EDO409 |
| B | HOH870 |
| site_id | CC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE B 417 |
| Chain | Residue |
| B | GLU211 |
| B | ALA214 |
| B | GLN215 |
| B | HOH524 |
| B | HOH544 |
| B | HOH605 |
| B | HOH751 |
| B | HOH756 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 418 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 419 |
| Chain | Residue |
| B | GLU109 |
| B | GLY189 |
| B | PHE306 |
| B | EDO402 |
| site_id | DC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 420 |
| Chain | Residue |
| B | ASP225 |
| B | HOH528 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 421 |
| Chain | Residue |
| B | HOH669 |
| B | HOH759 |
| B | HOH852 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 422 |
| Chain | Residue |
| B | ASP225 |
| B | SER249 |
| B | HOH821 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 423 |
| Chain | Residue |
| B | PHE12 |
| B | PRO285 |
| B | PGE403 |
| B | HOH516 |
| B | HOH739 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG |
| Chain | Residue | Details |
| A | LEU48-GLY61 | |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ |
| Chain | Residue | Details |
| B | LEU80-GLN94 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| B | LYS87 | |
| A | ASP60 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 383 |
| Chain | Residue | Details |
| B | LYS87 | electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLU109 | |
| B | SER377 | hydrogen bond donor |
