4HPJ

Crystal structure of Tryptophan Synthase at 1.45 A resolution in complex with 2-aminophenol quinonoid in the beta site and the F9 inhibitor in the alpha site

Summary for 4HPJ

Entry DOI	10.2210/pdb4hpj/pdb
Related	3CEP 3PR2 4HN4 4HPX 4HT3
Descriptor	Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (9 entities in total)
Functional Keywords	lyase, carbon-oxygen lyase, tryptophan biosynthesis, salmonella, f9f, allosteric enzyme, amino-acid biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, alpha amino acrylate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium More
Total number of polymer chains	2
Total formula weight	73509.86
Authors	Hilario, E.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2012-10-23, release date: 2013-12-25, Last modification date: 2023-09-20)
Primary citation	Niks, D.,Hilario, E.,Dierkers, A.,Ngo, H.,Borchardt, D.,Neubauer, T.J.,Fan, L.,Mueller, L.J.,Dunn, M.F. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52:6396-6411, 2013 Cited by PubMed: 23952479 DOI: 10.1021/bi400795e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation