4HPX

Crystal structure of Tryptophan Synthase at 1.65 A resolution in complex with alpha aminoacrylate E(A-A) and benzimidazole in the beta site and the F9 inhibitor in the alpha site

Summary for 4HPX

• Entry DOI: 10.2210/pdb4hpx/pdb
• Related: 1A5S 2J9X 4HN4 4HPX 4HT3
• Descriptor: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (9 entities in total)
• Functional Keywords: lyase, carbon-oxygen lyase, tryptophan biosynthesis, salmonella, f9f, benzimidazole, allosteric enzyme, amino-acid biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, alpha amino acrylate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium; More
• Total number of polymer chains: 2
• Total formula weight: 73939.43

Authors

Hilario, E.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2012-10-24, release date: 2013-12-18, Last modification date: 2023-09-20)

• Primary citation: Niks, D.,Hilario, E.,Dierkers, A.,Ngo, H.,Borchardt, D.,Neubauer, T.J.,Fan, L.,Mueller, L.J.,Dunn, M.F.; Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states.; Biochemistry, 52:6396-6411, 2013; PubMed: 23952479; DOI: 10.1021/bi400795e

Experimental method

X-RAY DIFFRACTION (1.65 Å)