1PY5

Crystal Structure of TGF-beta receptor I kinase with inhibitor

Summary for 1PY5
Related1PYE
DescriptorTGF-beta receptor type I, SULFATE ION, 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE, ... (4 entities in total)
Functional Keywordstgf-beta, receptor i, kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P36897
Total number of polymer chains1
Total formula weight37470.96
Authors
Zhang, F.,Sawyer, J.S. (deposition date: 2003-07-08, release date: 2004-07-13, Last modification date: 2011-07-13)
Primary citationAnderson, B.D.,Beight, D.W.,Britt, K.S.,Campbell, R.M.,Goodson, T.,Herron, D.K.,Li, H.Y.,McMillen, W.T.,Mort, N.,Parsons, S.,Sawyer, J.S.,Smith, E.C.,Wagner, J.R.,Yan, L.,Yingling, J.M.,Zhang, F.
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Bioorg.Med.Chem.Lett., 14:3581-3584, 2004
PubMed: 15177479
DOI: 110.1016/j.bmcl.2004.04.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-16