PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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5W7X	Crystal Structure of FHA domain of human APLF in complex with XRCC1 bisphospho peptide 分子名称: Aprataxin and PNK-like factor, DNA repair protein XRCC1 著者 Pedersen, L.C, Kim, K, London, R.E. 登録日 2017-06-21 公開日 2018-05-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.005 Å) 主引用文献 Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications. Nucleic Acids Res., 45, 2017
5WTB	Complex Structure of Staphylococcus aureus SdrE with human complement factor H 分子名称: Peptide from Complement factor H, Serine-aspartate repeat-containing protein E 著者 Wu, M, Zhang, Y, Hang, T, Wang, C, Yang, Y, Zang, J, Zhang, M, Zhang, X. 登録日 2016-12-10 公開日 2017-07-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion Biochem. J., 474, 2017
6DRG	NMR solution structure of wild type hFABP1 with GW7647 分子名称: 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid, Fatty acid-binding protein, liver 著者 Scanlon, M.J, Mohanty, B, Doak, B.C, Patil, R. 登録日 2018-06-11 公開日 2018-12-26 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor alpha agonists. J. Biol. Chem., 294, 2019
5WHA	KRas G12V, bound to GDP and miniprotein 225-11 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. 登録日 2017-07-16 公開日 2018-01-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Exceptionally high-affinity Ras binders that remodel its effector domain. J. Biol. Chem., 293, 2018
5WHC	USP7 in complex with Cpd2 (4-(3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl)phenol) 分子名称: 4-[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7 著者 Murray, J.M, Rouge, L. 登録日 2017-07-16 公開日 2017-12-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.548 Å) 主引用文献 Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques. J. Med. Chem., 60, 2017
6DA3	Human CYP3A4 bound to an inhibitor 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2R)-1-{[(2R)-1-oxo-3-phenyl-1-{[(pyridin-3-yl)methyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate 著者 Sevrioukova, I.F. 登録日 2018-05-01 公開日 2019-04-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4. Biochemistry, 58, 2019
5WJ3	Crystal structure of green fluorescent protein Clover mutant S147C/Q204C 分子名称: Green fluorescent protein 著者 Liu, C, Campbell, B.C, Petsko, G.A. 登録日 2017-07-21 公開日 2018-01-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.351 Å) 主引用文献 Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors. Structure, 26, 2018
2P82	Cysteine protease ATG4A 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Cysteine protease ATG4A 著者 Walker, J.R, Davis, T, Mujib, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2007-03-21 公開日 2007-04-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Human cysteine protease ATG4A To be Published
5XS2	CDK8-CYCC IN COMPLEX WITH COMPOUND 17:3-chloro-4-(4-pyridyl)-1H-pyrrole-2-carboxamide 分子名称: 3-chloranyl-4-pyridin-4-yl-1H-pyrrole-2-carboxamide, Cyclin-C, Cyclin-dependent kinase 8, ... 著者 Zhou, Z, Xu, Z. 登録日 2017-06-12 公開日 2017-08-09 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Discovery of potent and selective CDK8 inhibitors through FBDD approach Bioorg. Med. Chem. Lett., 27, 2017
6ASB	CXXC and PHD-type zinc finger regions of FBXL19 in complex with DNA 分子名称: DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), F-box/LRR-repeat protein 19, ZINC ION 著者 Liu, K, Tempel, W, Walker, J.R, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2017-08-24 公開日 2017-10-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Structure, 26, 2018
6ANJ	Synaptotagmin-7, C2A domain 分子名称: ACETATE ION, CALCIUM ION, Synaptotagmin-7, ... 著者 Tomchick, D.R, Rizo, J, Voleti, R. 登録日 2017-08-13 公開日 2017-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.698 Å) 主引用文献 Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5B7V	Human FGFR1 kinase in complex with CH5183284 分子名称: Fibroblast growth factor receptor 1, SULFATE ION, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone 著者 Fukami, T.A, Lukacs, C.M, Janson, C. 登録日 2016-06-09 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor Mol.Cancer Ther., 13, 2014
5X3Y	Refined solution structure of musashi1 RBD2 分子名称: RNA-binding protein Musashi homolog 1 著者 Iwaoka, R, Nagata, T, Tsuda, K, Imai, T, Okano, H, Kobayashi, N, Katahira, M. 登録日 2017-02-09 公開日 2017-12-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA Molecules, 22, 2017
5X67	Human thymidylate synthase in complex with dUMP and nolatrexed 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one, Thymidylate synthase 著者 Chen, D, Jansson, A, Larsson, A, Nordlund, P. 登録日 2017-02-21 公開日 2017-06-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. J. Biol. Chem., 292, 2017
5XCO	Crystal structure of human K-Ras G12D Mutant in complex with GDP and Cyclic Inhibitory Peptide 分子名称: 1,2-ETHANEDIOL, ACE-ARG-ARG-ARG-ARG-CYS-PRO-LEU-TYR-ILE-SER-TYR-ASP-PRO-VAL-CYS-ARG-ARG-ARG-ARG-NH2, GTPase KRas, ... 著者 Sogabe, S, Miwa, M. 登録日 2017-03-23 公開日 2017-05-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d ACS Med Chem Lett, 8, 2017
6AXF	Structure of RasGRP2 in complex with Rap1B 分子名称: RAS guanyl-releasing protein 2, Ras-related protein Rap-1b 著者 Kondo, Y, Iwig, J.S, Kuriyan, J. 登録日 2017-09-06 公開日 2017-10-11 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife, 6, 2017
6AP0	Crystal structure of human FLASH N-terminal domain C54S/C83A (Crystal form 2) 分子名称: CASP8-associated protein 2 著者 Aik, W.S, Tong, L. 登録日 2017-08-16 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.581 Å) 主引用文献 The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. PLoS ONE, 12, 2017
6DO6	NMR solution structure of wild type apo hFABP1 at 308 K 分子名称: Fatty acid-binding protein, liver 著者 Scanlon, M.J, Mohanty, B, Doak, B.C, Patil, R. 登録日 2018-06-09 公開日 2018-12-26 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor alpha agonists. J. Biol. Chem., 294, 2019
4H9N	Complex structure 1 of DAXX/H3.3(sub5)/H4 分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ... 著者 Elsasser, S.J, Huang, H, Lewis, P.W, Chin, J.W, Allis, D.C, Patel, D.J. 登録日 2012-09-24 公開日 2012-10-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published
5B16	X-ray structure of DROSHA in complex with the C-terminal tail of DGCR8. 分子名称: Microprocessor complex subunit DGCR8, Ribonuclease 3,DROSHA,Ribonuclease 3,DROSHA,Ribonuclease 3, ZINC ION 著者 Kwon, S.C, Nguyen, T.A, Choi, Y.G, Jo, M.H, Hohng, S, Kim, V.N, Woo, J.S. 登録日 2015-11-23 公開日 2016-02-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of Human DROSHA Cell, 164, 2016
5BSA	Structure of histone H3/H4 in complex with Spt2 分子名称: Histone H3.2, Histone H4, Protein SPT2 homolog 著者 Chen, S, Patel, D.J. 登録日 2015-06-01 公開日 2015-07-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (4.611 Å) 主引用文献 Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev., 29, 2015
6A9C	Crystal Structure c-terminal SH3 domain of Myosin IB from Entamoeba histolytica bound to EhFP10(GEF) peptide. 分子名称: Peptide from Rho guanine nucleotide exchange factor, SULFATE ION, Unconventional myosin IB 著者 Gautam, G, Gourinath, S. 登録日 2018-07-13 公開日 2019-06-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 EhFP10: A FYVE family GEF interacts with myosin IB to regulate cytoskeletal dynamics during endocytosis in Entamoeba histolytica. Plos Pathog., 15, 2019
4H7X	Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1 分子名称: Dual specificity protein kinase TTK, LEAD (II) ION 著者 Bolanos-Garcia, V.M, Chirgadze, D.Y, Blundell, T.L. 登録日 2012-09-21 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem.J., 448, 2012
6DA2	Human CYP3A4 bound to an inhibitor 分子名称: Cytochrome P450 3A4, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Sevrioukova, I.F. 登録日 2018-05-01 公開日 2019-04-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4. Biochemistry, 58, 2019
4N40	Crystal structure of human Epithelial cell-transforming sequence 2 protein 分子名称: Protein ECT2 著者 Zou, Y, Shao, Z.H, Li, F.D, Gong, D, Wang, C, Gong, Q, Shi, Y. 登録日 2013-10-08 公開日 2014-08-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (3.106 Å) 主引用文献 Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 Febs Lett., 588, 2014

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